ArticlePsychological medicine2018
Moderation of prior exposure to trauma on the inverse relationship between callous-unemotional traits and amygdala responses to fearful expressions: an exploratory study.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Emotion processing in youths with conduct problems: an fMRI meta-analysis.Translational psychiatry · 2023Pooled it
- Role of Callous and Unemotional (CU) Traits on the Development of Youth with Behavioral Disorders: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Independent Impacts of Maltreatment and Amygdala Volume on Worsening Callous-Unemotional Traits in High-Risk Youths.Research on child and adolescent psychopathology · 2025Article
- Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents.Research on child and adolescent psychopathology · 2024Article
- The Emotionally Sensitive Child-Adverse Parenting Experiences-Allostatic (Over)Load (ESCAPE-AL) Model for the Development of Secondary Psychopathic Traits.Clinical child and family psychology review · 2023Article
- Raging Hormones: Why Age-Based Etiological Conceptualizations of the Development of Antisocial Behavior Are Insufficient.Frontiers in behavioral neuroscience · 2022Review
- Callous-Unemotional Features are Associated with Emotion Recognition Impairments in Young ODD Children with Low but not High Affective Arousal.Child psychiatry and human development · 2021Article
- Neural Responses to Fluoxetine in Youths with Disruptive Behavior and Trauma Exposure: A Pilot Study.Journal of child and adolescent psychopharmacology · 2021Article
- Reduced neural responsiveness to looming stimuli is associated with increased aggression.Social cognitive and affective neuroscience · 2021Article
- Thinking about Others' Minds: Mental State Inference in Boys with Conduct Problems and Callous-Unemotional Traits.Journal of abnormal child psychology · 2020Article
- Recent neuro-imaging findings with respect to conduct disorder, callous-unemotional traits and psychopathy.Current opinion in psychiatry · 2020Review
- Genetic underpinnings of callous-unemotional traits and emotion recognition in children, adolescents, and emerging adults.Journal of child psychology and psychiatry, and allied disciplines · 2019Article
- How can (or could) biology inform more effective parenting interventions for childhood aggression?Aggression and violent behaviorArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPrevious work has shown that amygdala responsiveness to fearful expressions is inversely related to level of callous-unemotional (CU) traits (i.e. reduced guilt and empathy) in youth with conduct problems. However, some research has suggested that the relationship between pathophysiology and CU traits may be different in those youth with significant prior trauma exposure.
methodsIn experiment 1, 72 youth with varying levels of disruptive behavior and trauma exposure performed a gender discrimination task while viewing morphed fear expressions (0, 50, 100, 150 fear) and Blood Oxygenation Level Dependent responses were recorded. In experiment 2, 66 of these youth performed the Social Goals Task, which measures self-reports of the importance of specific social goals to the participant in provoking social situations.
resultsIn experiment 1, a significant CU traits-by-trauma exposure interaction was observed within right amygdala; fear intensity-modulated amygdala responses negatively predicted CU traits for those youth with low levels of trauma but positively predicted CU traits for those with high levels of trauma. In experiment 2, a bootstrapped model revealed that the indirect effect of fear intensity amygdala response on social goal importance through CU traits is moderated by prior trauma exposure.
conclusionsThis study, while exploratory, indicates that the pathophysiology associated with CU traits differs in youth as a function of prior trauma exposure. These data suggest that prior trauma exposure should be considered when evaluating potential interventions for youth with high CU traits.
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