ArticleJournal of psychiatric research2018
Seasonality of cerebrospinal fluid monoamine metabolite concentrations and their associations with meteorological variables in humans.
Article in Journal of psychiatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Sex Differences in Tryptophan Metabolism: A Systematic Review Focused on Neuropsychiatric Disorders.International journal of molecular sciences · 2023Pooled it
- An acute intervention experimental study on the effects of green and blue environment exposure combined with tai chi exercise on the emotional health of elderly males.Frontiers in psychology · 2026Article
- Urine 5-HIAA and quality of life in neuroendocrine neoplasia. Is there an association?Rare tumors · 2026Article
- Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health.Genome medicine · 2025Article
- Association Study of Serotonin 1A Receptor Gene, Personality, and Anxiety in Women with Alcohol Use Disorder.International journal of molecular sciences · 2024Article
- The effects of ambient temperature on road traffic injuries in Jinan city: a time-stratified case-crossover study based on distributed lag nonlinear model.Frontiers in public health · 2024Article
- A Systematic Review on the Impact of Seasonality on Severe Mental Illness Admissions: Does Seasonal Variation Affect Coercion?Healthcare (Basel, Switzerland) · 2023Review
- [Study of the photoperiodic dynamics of the peripheral dopamine content in comparison with the thyroid profile in various groups of men from the European North].Problemy endokrinologii · 2023Article
- Association between High Ambient Temperatures and Road Crashes in an Australian City with Temperate Climate: A Time-Series Study, 2012-2021.International journal of environmental research and public health · 2023Article
- Temperature-related mortality in China from specific injury.Nature communications · 2023Article
- Prevention of suicides associated with global warming: perspectives from early career psychiatrists.Frontiers in psychiatry · 2023Article
- Association between ambient temperatures and injuries: a time series analysis using emergency ambulance dispatches in Chongqing, China.Environmental health and preventive medicine · 2023Article
- Mechanisms by which adverse childhood experiences, other traumas and PTSD influence the health and well-being of individuals with eating disorders throughout the life span.Journal of eating disorders · 2022Review
- Effects of extreme precipitation on hospital visit risk and disease burden of depression in Suzhou, China.BMC public health · 2022Article
- The seasonal pattern of restless legs syndrome in a sample from the Korean Health Insurance Review and Assessment Service national database.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Effect of apparent temperature on daily emergency admissions for mental and behavioral disorders in Yancheng, China: a time-series study.Environmental health : a global access science source · 2019Article
- Suicide and Ambient Temperature: A Multi-Country Multi-City Study.Environmental health perspectives · 2019Article
- Heart rate variability related to season of birth: A replication study.Psychophysiology · 2019Article
- Seasonality of Suicides among Victims Who Are under the Influence of Alcohol.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Seasonal variations in neurotransmitter parameters have been previously reported in humans. However, these studies have involved small sample sizes and have not examined possible relationships with meteorological variables. We compared cerebrospinal fluid (CSF) concentrations of the major monoamine neurotransmitter metabolites (5-HIAA, HVA, and MHPG) in 188 healthy controls (80 men, 108 women) in relationship to age, sex, BMI, and available meteorological variables. All subjects had a lumbar puncture (LP) performed at 9 a.m. after overnight stay. Meteorological data for the day prior to LP were obtained from the National Climatic Association and included the photoperiod, percent sunshine, temperature (max, min, mean), barometric pressure, relative humidity, amount of precipitation and sky cover. Results revealed differences across seasons and cross-seasons for CSF 5-HIAA (p ≤ .05), with post-hoc differences emerging between spring versus summer and fall and between x-spring and x-summer (p ≤ .05). Differences were also found across seasons for CSF HVA (p ≤ .05) with post-hoc differences between spring versus fall. CSF 5-HIAA was significantly inversely correlated with maximum (r = -.28, p ≤ .02), minimum (r = -.24, p ≤ .04), and mean temperature (r = -.28, p ≤ .02) in men. In women, 5-HIAA (r = -.22, p ≤ .02) and HVA (r = -.28, p ≤ .003) were significantly correlated with relative humidity. These data confirm previous findings of variations in serotonin and dopamine metabolites across the year and highlight possible underlying mechanisms involving meteorological changes, which may result in alterations in neurophysiology and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.