ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2018
Comparative genome analysis reveals a complex population structure of Legionella pneumophila subspecies.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- From Investigating a Case of Cellulitis to Exploring Nosocomial Infection Control of ST1Microorganisms · 2024Article
- ReporType: A Flexible Bioinformatics Tool for Targeted Loci Screening and Typing of Infectious Agents.International journal of molecular sciences · 2024Article
- Development of heat-shock resistance inApplied and environmental microbiology · 2023Article
- Detection of Diverse Sequence Types of Legionella pneumophila by Legiolert Enzymatic-Based Assay and the Development of a Long-Term Storage Protocol.Microbiology spectrum · 2022Article
- Review
- Genomic characterization and assessment of pathogenic potential ofFrontiers in microbiology · 2022Article
- Legionella and other opportunistic pathogens in full-scale chloraminated municipal drinking water distribution systems.Water research · 2021Article
- Occurrence ofPathogens (Basel, Switzerland) · 2021Article
- Virulence effector SidJ evolution inPeerJ · 2021Article
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- Comparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016.Emerging infectious diseases · 2019Article
- Legionnaires' Disease Mortality in Guinea Pigs Involves the p45 Mobile Genomic Element.The Journal of infectious diseases · 2019Article
- Analysis of Genetic Characterization and Clonality ofInternational journal of environmental research and public health · 2019Article
- Draft Genome Sequences of Seven Legionella pneumophila Isolates from a Hot Water System of a Large Building.Microbiology resource announcements · 2019Article
- Legionella pneumophila p45 element influences host cell entry and sensitivity to sodium.PloS one · 2019Article
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10 authors.
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Abstract
The majority of Legionnaires' disease (LD) cases are caused by Legionella pneumophila, a genetically heterogeneous species composed of at least 17 serogroups. Previously, it was demonstrated that L. pneumophila consists of three subspecies: pneumophila, fraseri and pascullei. During an LD outbreak investigation in 2012, we detected that representatives of both subspecies fraseri and pascullei colonized the same water system and that the outbreak-causing strain was a new member of the least represented subspecies pascullei. We used partial sequence based typing consensus patterns to mine an international database for additional representatives of fraseri and pascullei subspecies. As a result, we identified 46 sequence types (STs) belonging to subspecies fraseri and two STs belonging to subspecies pascullei. Moreover, a recent retrospective whole genome sequencing analysis of isolates from New York State LD clusters revealed the presence of a fourth L. pneumophila subspecies that we have termed raphaeli. This subspecies consists of 15 STs. Comparative analysis was conducted using the genomes of multiple members of all four L. pneumophila subspecies. Whereas each subspecies forms a distinct phylogenetic clade within the L. pneumophila species, they share more average nucleotide identity with each other than with other Legionella species. Unique genes for each subspecies were identified and could be used for rapid subspecies detection. Improved taxonomic classification of L. pneumophila strains may help identify environmental niches and virulence attributes associated with these genetically distinct subspecies.
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