ArticleDiabetes research and clinical practice2018
Pregnancy outcomes in women with an early diagnosis of gestational diabetes mellitus.
Article in Diabetes research and clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Early-Onset Versus Late-Onset Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Maternal, Perinatal and Neonatal Outcomes.Diabetes, obesity & metabolism · 2026Pooled it
- Global burden of early pregnancy gestational diabetes mellitus (eGDM): A systematic review.Acta diabetologica · 2022Pooled it
- The association between early diagnosis of gestational diabetes and maternal-neonatal outcomes: a secondary analysis of the digest trial.Endocrine · 2026Trial
- Does fasting plasma glucose values 5.1-5.6 mmol/l in the first trimester of gestation a matter?Frontiers in endocrinology · 2023Trial
- Early gestational diabetes screening in obese women: a randomized controlled trial.American journal of obstetrics and gynecology · 2020Trial
- Obstacles and Enablers Related to Gestational Diabetes Self-Management: Systematic Review Using the Socio-Eecological Model.JMIR diabetes · 2026Review
- Observational
- Understanding gestational diabetes in Hong Kong: women's needs, self-management challenges, and the potential of digital health solutions in culturally sensitive care.BMC pregnancy and childbirth · 2025Article
- Maternal and neonatal outcomes according to the timing of diagnosis of gestational diabetes: A critical appraisal.World journal of diabetes · 2025Review
- Navigating Diabetes in Pregnancy: Critical Approaches to Mitigate Risks and Improve Outcomes for Mother and Child.Metabolites · 2025Review
- The Association Between Glucose Variability and Insulin Parameters in Gestational Diabetes Diagnosed After 24 Gestational Weeks.Nutrients · 2025Article
- Multiple positive points during the 75 g oral glucose tolerance test are good predictors for early insulin therapy in gestational diabetes mellitus diagnosed before 24 gestational weeks.Journal of diabetes investigation · 2024Article
- Perinatal Outcomes of Diet Therapy in Gestational Diabetes Mellitus Diagnosed before 24 Gestational Weeks.Nutrients · 2024Article
- Circulating lncRNAs NONHSAT054669.2 and ENST00000525337 can be used as early biomarkers of gestational diabetes mellitus.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Study on the Relationship and Predictive Value of First-Trimester Pregnancy-Associated Plasma Protein-A, Maternal Factors, and Biochemical Parameters in Gestational Diabetes Mellitus: A Large Case-Control Study in Southern China Mothers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Impact of earlier gestational diabetes screening for pregnant people with obesity on maternal and perinatal outcomes.Journal of perinatal medicine · 2022Article
- Pregnancy Outcomes Associated with Introduction of Early Diabetes Screening Guidelines.American journal of perinatology · 2022Article
- DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks.BMJ open diabetes research & care · 2022Article
- Population-based study on birth outcomes among women with hypertensive disorders of pregnancy and gestational diabetes mellitus.Scientific reports · 2021Article
- Fetal Abdominal Obesity Detected At 24 to 28 Weeks of Gestation Persists Until Delivery Despite Management of Gestational Diabetes Mellitus.Diabetes & metabolism journal · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo examine pregnancy outcomes in women with gestational diabetes mellitus (GDM) based on the timing of diagnosis.
methodWe compared demographics, blood sugars and outcomes between women diagnosed before (n = 167) or after 24 weeks' gestation (n = 1202) in a single hospital between 2009 and 2012. Because early screening is risk-based we used propensity score modelling and conditional logistic regression to account for systematic differences.
resultsWomen diagnosed with GDM before 24 weeks were more likely to be obese and they were less likely to have excess gestational weight gain (35 vs. 45%, p = 0.04). Early diagnosis was associated with more frequent therapy including glyburide (65 vs. 56%, p < 0.001) and insulin (19 vs 6%, p < 0.001). After propensity score modelling and accounting for covariates, early diagnosis was associated with an increased risk for macrosomia (OR 2, 95% 1-4.15, p = 0.0498). Early diagnosis was not associated with other adverse outcomes. In a subgroup analysis comparing women treated with glyburide prior to 24 weeks compared to those diagnosed after 24 weeks, early diagnosis in women treated with glyburide was associated with an increased risk for macrosomia (OR 2.3, 95% CI 1.1-5.4, P = 0.04).
conclusionWomen diagnosed with GDM before 24 weeks have unique features, are at risk for adverse outcomes, and require targeted approaches to therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.