Evidence map›Paper›PMID 29427415›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin.

Michelle L McCully, Kristin Ladell, Robert Andrews, Rhiannon E Jones, Kelly L Miners, Laureline Roger, Duncan M Baird, Mark J Cameron, Zita M Jessop, Iain S Whitaker and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Expansion of multiple CD4The Journal of allergy and clinical immunology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Novel Prognostic Markers for Skin Cutaneous Melanoma.Clinical, cosmetic and investigational dermatology · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Human T lymphocytes at tumor sites.Seminars in immunopathology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Michelle L McCullyDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-9856-2938
Robert AndrewsSystems Immunity Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0002-3491-2361
Rhiannon E JonesSystems Immunity Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Kelly L MinersDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Laureline RogerDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Duncan M BairdSystems Immunity Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.ORCID 0000-0001-8408-5467
Mark J CameronDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106.ORCID 0000-0003-4768-4094
Zita M JessopThe Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA6 6NL, United Kingdom; and.ORCID 0000-0003-2886-9165
Iain S WhitakerThe Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea SA6 6NL, United Kingdom; and.
Eleri L DaviesBreast Centre, University Hospital of Llandough, Llandough CF64 2XX, United Kingdom.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom.
Bernhard MoserDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom; moserb@cardiff.ac.uk.ORCID 0000-0002-4354-4572
University of Wales Institute Cardiff · SGMorriston Hospital · GBCase Western Reserve University · USInstitute of Infection and Immunity · CAUniversity Hospital Llandough · GB

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
Cancer Research UK 18246Medical Research Council MR/L018284/1Medical Research Council MR/N002431/1NIAID NIH HHS P30 AI036219Wellcome Trust 092488/Z/10/Z
6 · The paper itself

Abstract

Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 expression is regulated by TCR engagement and the skin tissue microenvironment. To extend these observations, we examined the relationship between CCR8

Indexed as

Antigens, CDBiomarkersCell DifferentiationHumansImmunologic MemoryLymphocyte ActivationReceptors, CCR8SkinT-LymphocytesAntigens, CDBiomarkersCCR8 protein, humanReceptors, CCR8

Identifiers

PMID29427415
PMCPMC5818732
OpenAlexW2786452152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.