Evidence map›Paper›PMID 29427325›Full record

ArticleMagnetic resonance in medicine2018

Controlling T

Li Zhao, Ching-Di Chang, David C Alsop

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  11. Regional and depth-dependence of cortical blood-flow assessed with high-resolution Arterial Spin Labeling (ASL).Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li ZhaoDepartment of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4933-3183
Ching-Di ChangDepartment of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, Massachusetts, USA.
David C AlsopDepartment of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, Massachusetts, USA.

Funding

Perfusion MRI for Multi-site Studies of Brain FunctionR01MH080729 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ALSOP, DAVID CHARLES, DETRE, JOHN A · 2007 to 2017
$3.8M
NIMH NIH HHS R01 MH080729
6 · The paper itself

Abstract

purposeTo improve the SNR efficiency and reduce the T

methodsAn algorithm for determining the optimal combination of variable flip angles and filtering correction is proposed. The flip angles are designed using extended phase graph physical simulations in an analytical and global optimization framework, with an optional constraint on deposited power. Optimal designs for correcting to Hann and Fermi window functions were compared with conventional constant amplitude or variable flip angle only designs on 6 volunteers.

resultsWith the Fermi window correction, the proposed optimal designs provided 39.8 and 27.3% higher SNR (P < .05) than conventional constant amplitude and variable flip angle designs. Even when power deposition was limited to 50% of the constant amplitude design, the proposed method outperformed the SNR (P < .05) of these 2 conventional approaches by 32.5 and 20.7%. The sharpness and the contrast between gray and white matter were improved with the k-space filtering correction for all of the flip angle designs. The improvements were moderate for the Hann window correction.

conclusionThis work demonstrates that variable flip angles can be derived as the output of an optimization problem. The combined design of variable flip angle and k-space filtering provided superior SNR to designs primarily emphasizing either approach singly.

Indexed as

Signal Processing, Computer-AssistedAlgorithmsBrainHumansImaging, Three-DimensionalMagnetic Resonance ImagingSignal-To-Noise RatioSpin LabelsSpin Labelsarterial spin labeling (ASL)k-space filteringrapid acquisition with relaxation enhancement (RARE)T2 blurringvariable flip angle

Identifiers

PMID29427325
PMCPMC6085152

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.