Evidence map›Paper›PMID 29427240›Full record

ArticleExperimental brain research2018

Bilateral deep brain stimulation of the subthalamic nucleus increases pointing error during memory-guided sequential reaching.

Fabian J David, Lisa C Goelz, Ruth Z Tangonan, Leonard Verhagen Metman, Daniel M Corcos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fabian J DavidDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, 645 North Michigan Avenue, Suite 1100, Chicago, IL, 60611, USA. Fabian.J.David@northwestern.edu.
Lisa C GoelzDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, 645 North Michigan Avenue, Suite 1100, Chicago, IL, 60611, USA.
Ruth Z TangonanCollege of Medicine, University of Illinois, Chicago, IL, USA.
Leonard Verhagen MetmanSection of Parkinson Disease and Movement Disorders, Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, 645 North Michigan Avenue, Suite 1100, Chicago, IL, 60611, USA.

Funding

Cortical priming to optimize gait rehabilitation post strokeR01HD075777 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MADHAVAN, SANGEETHA · 2014 to 2024
$4.1M
Exploratory study of different doses of endurance exercise in people with ParkinsR01NS074343 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CORCOS, DANIEL M., SCHENKMAN, MARGARET L · 2011 to 2014
$3.0M
Effect of Unilateral and Bilateral STN Stimulation on Eye-Hand CoordinationR01NS092950 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CORCOS, DANIEL M. · 2016 to 2020
$1.5M
Intensive Rehabilitation Research Grant Writing Workshops in the United StatesT15HD074546 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEGAL, RICHARD L · 2013 to 2017
$606k
STN Stimulation: Neural Control of Movement and PostureR56NS040902 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CORCOS, DANIEL M. · 2011 to 2011
$364k
NICHD NIH HHS R01 HD075777NICHD NIH HHS T15 HD074546NIH HHS 1R01NS092950NIH HHS R56NS040902NINDS NIH HHS R01 NS074343NINDS NIH HHS R01 NS092950NINDS NIH HHS R56 NS040902
6 · The paper itself

Abstract

Deep brain stimulation of the subthalamic nucleus (STN DBS) significantly improves clinical motor symptoms, as well as intensive aspects of movement like velocity and amplitude in patients with Parkinson's disease (PD). However, the effects of bilateral STN DBS on integrative and coordinative aspects of motor control are equivocal. The aim of this study was to investigate the effects of bilateral STN DBS on integrative and coordinative aspects of movement using a memory-guided sequential reaching task. The primary outcomes were eye and finger velocity and end-point error. We expected that bilateral STN DBS would increase reaching velocity. More importantly, we hypothesized that bilateral STN DBS would increase eye and finger end-point error and this would not simply be the result of a speed accuracy trade-off. Ten patients with PD and bilaterally implanted subthalamic stimulators performed a memory-guided sequential reaching task under four stimulator conditions (DBS-OFF, DBS-LEFT, DBS-RIGHT, and DBS-BILATERAL) over 4 days. DBS-BILATERAL significantly increased eye velocity compared to DBS-OFF, DBS-LEFT, and DBS-RIGHT. It also increased finger velocity compared to DBS-OFF and DBS-RIGHT. DBS-BILATERAL did not change eye end-point error. The novel finding was that DBS-BILATERAL increased finger end-point error compared to DBS-OFF, DBS-LEFT, and DBS-RIGHT even after adjusting for differences in velocity. We conclude that bilateral STN DBS may facilitate basal ganglia-cortical networks that underlie intensive aspects of movement like velocity, but it may disrupt selective basal ganglia-cortical networks that underlie certain integrative and coordinative aspects of movement such as spatial accuracy.

Indexed as

Deep Brain StimulationAgedCognitive DysfunctionFemaleHumansMaleMiddle AgedMotor ActivityMovementParkinson DiseasePsychomotor PerformanceSerial LearningSubthalamic NucleusDeep brain stimulationMemory-guidedParkinson diseaseSequential reachSTN DBSSubthalamic nucleus

Identifiers

PMID29427240
PMCPMC5889310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.