ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018
Neoadjuvant Radiation Therapy in Locally Advanced Colon Cancer: a Cohort Analysis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06244537 (Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Safety and Efficacy of MR-Linac Technique in Patients With Unresectable Locally Advanced Colon Cancer
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Partial versus radical cystectomy in localized colorectal cancer: a systematic review and meta-analysis.International urology and nephrology · 2025Pooled it
- Assessing the Effect of Radiotherapy in Addition to Surgery in Colon Adenocarcinomas: a Systematic Review and Meta-analysis of Contemporary Evidence.Journal of gastrointestinal cancer · 2020Pooled it
- Postoperative locoregional recurrence pattern and treatment management of stage pT4 sigmoid colon cancer: a retrospective cohort study.Radiation oncology (London, England) · 2022Trial
- A quest for sphincter-saving surgery in ultralow rectal tumours-a single-centre cohort study.World journal of surgical oncology · 2018Trial
- Case Report: Innovative radiotherapy strategies in advanced colon cancer with oligometastasis: a case of online adaptive radiotherapy and lattice stereotactic re-irradiation.Frontiers in oncology · 2026Article
- Mapping the landscape of locally advanced colon cancer research: a 30-year bibliometric perspective.Discover oncology · 2025Article
- Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy for initially unresectable locally advanced colon cancer: short-term outcomes of an open-label, single-centre, randomised, controlled, phase 3 trial.EClinicalMedicine · 2024Article
- LncRNA HOTAIR promotes DNA damage repair and radioresistance by targeting ATR in colorectal cancer.Oncology research · 2024Article
- Definitive Chemoradiation for Colon Cancer: a Case Report.Journal of gastrointestinal cancer · 2023Article
- Adaptive radiotherapy of locally advanced sigmoid colon cancer with intra‑fractional motion using the MRIdian system: A case report.Oncology letters · 2023Article
- Optimal treatment strategy and prognostic analysis for patients with non-metastatic pT4 colon adenocarcinoma.Frontiers in oncology · 2023Article
- Outcomes of Partial or Total Cystectomy in Advanced Colon Cancer with Suspected Bladder Invasion-Our 8-Year Experience and Literature Review.Journal of gastrointestinal cancer · 2022Review
- Prognostic analysis and beneficiary identification of adjuvant external beam radiotherapy for stage pT4b sigmoid colon cancer.Scientific reports · 2021Article
- Interventions and Outcomes for Neoadjuvant Treatment of T4 Colon Cancer: A Scoping Review.Current oncology (Toronto, Ont.) · 2021Article
- Observational
- Critical reappraisal of neoadjuvant concurrent chemoradiotherapy for treatment of locally advanced colon cancer.PloS one · 2021Article
- Preoperative radiation as part of a multidisciplinary strategy for a medically inoperable patient with a bleeding colon cancer.BMJ case reports · 2019Article
- How to save both transverse colon and continence after extensive left colon surgery: A case report of a new procedure.International journal of surgery case reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA paucity of data exists in the use of neoadjuvant chemoradiation therapy (NRT) for T4, non-metastatic colon cancer. This study was conducted to determine the effect of NRT on outcomes after resection for T4 colon cancer.
methodsAll patients with non-metastatic resected clinical T4 colon cancer from 2000 to 2012 at a tertiary care center were included. The cohort was divided into two groups-those that received NRT and those that did not (non-NRT). The primary outcomes were margin-negative resection and overall survival (OS).
resultsOne hundred and thirty-one consecutive patients with non-metastatic clinical T4 colon cancer with a mean age of 65 years were included. NRT was used in 23 patients (17.4%). NRT group was noted to have non-statistically significant improvement in R0 resection rate (NRT 95.7% vs non-NRT 88.0%; p = 0.27) and local recurrence (NRT 4.3% vs non-NRT 15.7%; p = 0.15). There was a significant difference in T-stage downstaging between the two groups (NRT 30.4% vs non-NRT 6.5%; p = 0.007). In a bivariate analysis, NRT was associated with improved 5-year OS (NRT 76.4% vs non-NRT 51.5%; p = 0.03). This relationship did not persist in a Cox proportional hazard analysis that included age and comorbidity (HR 2.19; 95% CI 0.87-5.52; p = 0.09).
conclusionsThe use of NRT in locally advanced T4 colon cancer is safe and associated with increased downstaging. While there was a trend toward improvement in local recurrence and the ability to obtain margin-negative resections in the NRT group, this was not significant. Significantly improved overall survival was not observed in a multivariable analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.