Evidence map›Paper›PMID 29427082›Full record

ArticleCancer immunology, immunotherapy : CII2018

Identification of tumor-reactive B cells and systemic IgG in breast cancer based on clonal frequency in the sentinel lymph node.

Jonathan R McDaniel, Stephanie C Pero, William N Voss, Girja S Shukla, Yujing Sun, Sebastian Schaetzle, Chang-Han Lee, Andrew P Horton, Seth Harlow, Jimmy Gollihar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Article
  3. CD4Nature cancer · 2023
    Review
  4. Review
  5. Antibody repertoire sequencing analysis.Acta biochimica et biophysica Sinica · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Jonathan R McDanielDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Stephanie C PeroDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA.
William N VossDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Girja S ShuklaDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA.
Yujing SunDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA.
Sebastian SchaetzleDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Chang-Han LeeDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Andrew P HortonDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Seth HarlowDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA.
Jimmy GolliharDepartment of Molecular Biosciences, The University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX, 78712, USA.
Jared W EllefsonDepartment of Molecular Biosciences, The University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX, 78712, USA.
Christopher C KragDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA.
Yuri TannoDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Nikoletta SidiropoulosDepartment of Pathology and Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA.
George GeorgiouDepartment of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
Gregory C IppolitoDepartment of Molecular Biosciences, The University of Texas at Austin, 100 E. 24th Street, Stop A5000, Austin, TX, 78712, USA. gci@mail.utexas.edu.
David N KragDepartment of Surgery, Vermont Cancer Center, University of Vermont Larner College of Medicine, 89 Beaumont Avenue, Given Medical Building, Burlington, VT, 05405, USA. David.Krag@uvm.edu.ORCID http://orcid.org/0000-0001-5355-5999
The University of Texas at Austin · USUniversity of Vermont · US

Funding

INVERTED LASER-SCANNING CONFOCAL MICROSCOPE: LUNG RESEARCHS10RR019246 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TAATJES, DOUGLAS J. · 2004 to 2004
$473k
Comprehensive functional assesment of the human antibody response to Enterovirus 71R21AI119368 · NIAID · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI DESSAIN, SCOTT KENDALL · 2016 to 2017
$458k
NCRR NIH HHS S10 RR019246NIAID NIH HHS R21 AI119368
6 · The paper itself

Abstract

A better understanding of antitumor immune responses is the key to advancing the field of cancer immunotherapy. Endogenous immunity in cancer patients, such as circulating anticancer antibodies or tumor-reactive B cells, has been historically yet incompletely described. Here, we demonstrate that tumor-draining (sentinel) lymph node (SN) is a rich source for tumor-reactive B cells that give rise to systemic IgG anticancer antibodies circulating in the bloodstream of breast cancer patients. Using a synergistic combination of high-throughput B-cell sequencing and quantitative immunoproteomics, we describe the prospective identification of tumor-reactive SN B cells (based on clonal frequency) and also demonstrate an unequivocal link between affinity-matured expanded B-cell clones in the SN and antitumor IgG in the blood. This technology could facilitate the discovery of antitumor antibody therapeutics and conceivably identify novel tumor antigens. Lastly, these findings highlight the unique and specialized niche the SN can fill in the advancement of cancer immunotherapy.

Indexed as

Amino Acid SequenceAntibodies, MonoclonalAntigens, NeoplasmB-LymphocytesBreast NeoplasmsCells, CulturedClone CellsFemaleHumansImmunoglobulin GSentinel Lymph NodeSequence HomologyAntibodies, MonoclonalAntigens, NeoplasmImmunoglobulin GAntibodyBreast cancerHeavy–light (VH:VL) chain pairingNext-Generation SequencingRepertoireSentinel Node

Identifiers

PMID29427082
PMCPMC6368991
OpenAlexW2766950032

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.