Evidence map›Paper›PMID 29427080›Full record

ArticlePsychopharmacology2018

Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference.

Ville Oinio, Mikko Sundström, Pia Bäckström, Johanna Uhari-Väänänen, Kalervo Kiianmaa, Atso Raasmaja, Petteri Piepponen

Abstract read
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Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ville OinioDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland. ville.oinio@helsinki.fi.ORCID http://orcid.org/0000-0001-7036-5417
Mikko SundströmDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Pia BäckströmDepartment of Health, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Johanna Uhari-VäänänenDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Kalervo KiianmaaDepartment of Health, National Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Atso RaasmajaDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.
Petteri PiepponenDepartment of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleComorbidity with gambling disorder (GD) and alcohol use disorder (AUD) is well documented.

objectiveThe purpose of our study was to examine the influence of genetic alcohol drinking tendency on reward-guided decision making behavior of rats and the impact of dopamine releaser D-amphetamine on this behavior.

methodsIn this study, Alko alcohol (AA) and Wistar rats went through long periods of operant lever pressing training where the task was to choose the profitable of two options. The lever choices were guided by different-sized sucrose rewards (one or three pellets), and the probability of gaining the larger reward was slowly changed to a level where choosing the smaller reward would be the most profitable in the long run. After training, rats were injected (s.c.) with dopamine releaser D-amphetamine (0.3, 1.0 mg/kg) to study the impact of rapid dopamine release on this learned decision making behavior.

resultsAdministration of D-amphetamine promoted unprofitable decision making of AA rats more robustly when compared to Wistar rats. At the same time, D-amphetamine reduced lever pressing responses. Interestingly, we found that this reduction in lever pressing was significantly greater in Wistar rats than in AA rats and it was not linked to motivation to consume sucrose.

conclusionsOur results indicate that conditioning to the lever pressing in uncertain environments is more pronounced in AA than in Wistar rats and indicate that the reinforcing effects of a gambling-like environment act as a stronger conditioning factor for rats that exhibit a genetic tendency for high alcohol drinking.

Indexed as

UncertaintyAlcoholismAnimalsChoice BehaviorConditioning, OperantDecision MakingDextroamphetamineDopamineDopamine Uptake InhibitorsDose-Response Relationship, DrugMaleMotivationRatsRats, WistarDextroamphetamineDopamineDopamine Uptake InhibitorsAlcohol use disorderD-AmphetamineDecision makingGamblingRats

Identifiers

PMID29427080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.