ReviewCurrent genetics2018
Perspective: challenges and opportunities for the study of cardiolipin, a key player in bacterial cell structure and function.
Review in Current genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Polymer-Coated Nanoarchitectonics of Titanium Dioxide Nanoparticles with Enhanced Antimicrobial Activity: Mechanistic Insights into Localized Particle-Membrane Interactions.ACS central science · 2026Article
- Conserved rod-to-spherical shape transitions in Escherichia coli through primordial experimental adaptations.Bioscience reports · 2026Article
- Exceptionally stable membrane lipid composition of the marine facultative anaerobe and piezotolerant 'Labilibaculum euxinus' under variable pressure and nutrients.FEMS microbiology ecology · 2026Article
- Multifaceted antimicrobial mechanisms of NCR147-derived peptides fromFrontiers in microbiology · 2025Article
- The role of lignin in 17β-estradiol biodegradation: insights from cellular characteristics and lipidomics.Microbial cell factories · 2024Article
- Insights into the Formation of Intermolecular Complexes of Fluorescent Probe 10-Molecules (Basel, Switzerland) · 2023Article
- Cardiolipin enhances the enzymatic activity of cytochrome bd and cytochrome boScientific reports · 2021Article
- Indirect Pathway Metabolic Engineering Strategies for Enhanced Biosynthesis of Hyaluronic Acid in EngineeredFrontiers in bioengineering and biotechnology · 2021Article
- Lipids that directly regulate innate immune signal transduction.Innate immunity · 2020Review
- Cardiolipin AltersmBio · 2019Article
- A promiscuous archaeal cardiolipin synthase enables construction of diverse natural and unnatural phospholipids.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiolipin (CL) is a key player in bacterial cell biology. CL accumulates at the poles of rod-shaped cells; the polar localization and function of diverse bacterial proteins are CL-dependent. Cardiolipin (CL) is an unusual phospholipid comprised of a glycerol headgroup coupled with two phosphatidate moieties. CL-rich membrane domains are often visualized with the fluorescent indicator 10-N-nonyl-acridine orange (NAO). Recent data show that NAO can also indicate phosphatidylglycerol localization under different experimental conditions, in the absence of CL. The formation of CL-rich membrane domains at bacterial cell poles was predicted to occur spontaneously, by lipid microphase separation arising from the conical CL shape. New data reveal that membrane-anchored cardiolipin synthase A is targeted to the cytoplasmic membrane surface at bacterial cell poles. Thus, localized CL synthesis, interaction of CL with ClsA, and membrane curvature could all contribute to retention of CL at cell poles. These observations provide new insight regarding the mechanism for assembly of CL-rich membrane domains in prokaryotes and eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.