Evidence map›Paper›PMID 29426942›Full record

ArticleScientific reports2018

Galectin-1 is required for the regulatory function of B cells.

R Alhabbab, P Blair, L A Smyth, K Ratnasothy, Q Peng, A Moreau, R Lechler, R Elgueta, G Lombardi

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. TIM3-mediated differentiation of IL-10-producing CD25Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  2. Role of Galectin-1 in the Pathogenesis of Melanoma.Journal of cancer science and clinical therapeutics · 2025
    Article
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  20. Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

R AlhabbabInfectious Disease Unit & Division of Applied Medical Sciences, King Fahad Centre for medical research, King Abdulaziz University, Jeddah, Saudi Arabia. rymalhabbab@kau.edu.sa.
P BlairDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
L A SmythDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
K RatnasothyDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
Q PengDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
A MoreauDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
R LechlerDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK.
R ElguetaDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK. raul.elgueta@kcl.ac.uk.
G LombardiDivision of Transplantation Immunology & Mucosal Biology, King's College London, King's Health Partners, Guy's Hospital, London, SE1 9RT, UK. giovanna.lombardi@kcl.ac.uk.
King's College London · GBKings Health Partners · GBGuy's Hospital · GB

Funding

NHLBI CLINICAL INVESTIGATOR AWARDK08HL001312 · NHLBI · LANKENAU HOSPITAL · PI MICHELSON, ERIC L · 1985 to 1987
–
British Heart Foundation PG/11/7/28621British Heart Foundation RG/08/005/25303British Heart Foundation RG/13/12/30395Medical Research Council MC_PC_14105Medical Research Council MR/J006742/1Medical Research Council MR/L022699/1
6 · The paper itself

Abstract

Galectin-1 (Gal-1) is required for the development of B cells in the bone marrow (BM), however very little is known about the contribution of Gal-1 to the development of B cell regulatory function. Here, we report an important role for Gal-1 in the induction of B cells regulatory function. Mice deficient of Gal-1 (Gal-1

Indexed as

Graft SurvivalLymphocyte ActivationAllograftsAnimalsB-Lymphocytes, RegulatoryDendritic CellsGalectin 1Interleukin-10MiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutSkin TransplantationT-LymphocytesTumor Necrosis Factor-alphaGalectin 1IL10 protein, mouseInterleukin-10Tumor Necrosis Factor-alpha

Identifiers

PMID29426942
PMCPMC5807431
OpenAlexW2791258865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.