ArticleScientific reports2018
Caffeine Caused a Widespread Increase of Resting Brain Entropy.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study.Journal of neuroscience research · 2026Article
- Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy.Nature communications · 2026Article
- Caffeine as an Ergogenic Aid for Neuromuscular Performance: Mechanisms of Action from Brain to Motor Units.Nutrients · 2026Review
- Brain entropy as a biomarker of major depression in adolescents and young adults: insights from multimodal resting-state functional magentic resonance imaging.Psychoradiology · 2026Article
- Caffeine induces age-dependent increases in brain complexity and criticality during sleep.Communications biology · 2025Article
- The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.Brain structure & function · 2025Article
- Severe Reversible Cerebral Vasospasm Syndrome Successfully Treated with Balloon Angioplasty and Intra-Arterial Nicardipine Infusion: A Case Report.Journal of neuroendovascular therapy · 2025Article
- Green tea consumption rapidly enhances cognitive performance and flow state during mental tasks in healthy young adults.PloS one · 2025Article
- Resting state fMRI-based temporal coherence mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.BMC neuroscience · 2024Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Divergent association between pain intensity and resting-state fMRI-based brain entropy in different age groups.Journal of neuroscience research · 2024Article
- Article
- Effects of green tea and roasted green tea on human responses.Scientific reports · 2024Article
- Task-induced changes in brain entropy.Journal of neuroscience research · 2024Article
- Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts.Medical & biological engineering & computing · 2023Article
- Caffeine, Postoperative Delirium And Change In Outcomes after Surgery (CAPACHINOS)-2: protocol for a randomised controlled trial.BMJ open · 2023Article
- Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic.Frontiers in psychiatry · 2023Article
- Brain entropy changes in classical trigeminal neuralgia.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entropy is an important trait of brain function and high entropy indicates high information processing capacity. We recently demonstrated that brain entropy (BEN) is stable across time and differs between controls and patients with various brain disorders. The purpose of this study was to examine whether BEN is sensitive to pharmaceutical modulations with caffeine. Both cerebral blood flow (CBF) and resting fMRI were collected from sixty caffeine-naïve healthy subjects before and after taking a 200 mg caffeine pill. Our data showed that caffeine reduced CBF in the whole brain but increased BEN across the cerebral cortex with the highest increase in lateral prefrontal cortex, the default mode network (DMN), visual cortex, and motor network, consistent with the beneficial effects of caffeine (such as vigilance and attention) on these areas. BEN increase was correlated to CBF reduction only in several regions (-0.5 < r < -0.4), indicating a neuronal nature for most of the observed BEN alterations. In summary, we showed the first evidence of BEN alterations due to caffeine ingestion, suggesting BEN as a biomarker sensitive to pharmaceutical brain function modulations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.