ArticleScientific reports2018
A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63citing papers in PubMed
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Who cites it
63 citing papers in PubMed, 109 citations in OpenAlex.
- Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial.Kidney360 · 2020Trial
- RhoA through its various effectors mediate mitochondrial fragmentation in polycystic kidney disease.iScience · 2026Article
- Modeling Complex Developmental Disease: The Case of Polycystic Kidney Disease.Journal of developmental biology · 2026Review
- Polycystin-1 and Cardiac Remodeling: From Mechanotransduction to Clinical Consequences.Circulation research · 2026Review
- Physiological functions and pharmacological targeting of transient receptor potential channels.Pharmacological reviews · 2025Review
- Cleavage of N-terminus of polycystin-1 increases calcium permeability of polycystin-1/2 receptor channel complexes.JCI insight · 2025Article
- Physiologic mechanisms underlying polycystic kidney disease.Physiological reviews · 2025Review
- Metabolic reprogramming in polycystic kidney disease and other renal ciliopathies.EMBO molecular medicine · 2025Review
- Ameliorative Effect of an Anti-MicroRNA-21 Oligonucleotide on Animal and Human Models of Cystic Kidney Disease.Kidney360 · 2025Article
- Eliosin-an alternative product from the HmPKD1 locus is a component of endoplasmic reticulum mitochondria membrane contact sites.PloS one · 2025Article
- The Influence of Non-Pharmacological and Pharmacological Interventions on the Course of Autosomal Dominant Polycystic Kidney Disease.Nutrients · 2024Review
- Kidney Energetics and Cyst Burden in Autosomal Dominant Polycystic Kidney Disease: A Pilot Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Acyl-CoA thioesterase 13 (Aging · 2024Article
- Comparative genomics reveals convergent signals associated with the high metabolism and longevity in birds and bats.Proceedings. Biological sciences · 2024Article
- Reprogramming of Energy Metabolism in HumanInternational journal of molecular sciences · 2024Article
- Inhibition of asparagine synthetase effectively retards polycystic kidney disease progression.EMBO molecular medicine · 2024Article
- Leucine-Rich Repeat in Polycystin-1 Suppresses Cystogenesis in a Zebrafish (International journal of molecular sciences · 2024Article
- A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Alpha-lipoic acid: A promising pharmacotherapy seen through the lens of kidney diseases.Current research in pharmacology and drug discovery · 2024Review
- Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease.iScience · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 7 institutions in 3 countries.
Cheng-Chao LinKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Mahiro KurashigeKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Yi LiuLaboratory of Molecular Genetics; National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Takeshi TerabayashiKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Yu IshimotoDivision of Nephrology and Endocrinology and the Division of CKD Pathophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Tanchun WangKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Vineet ChoudharyLaboratory of Cell and Molecular Biology; National Institute of Diabetes and Digestive and Kidney Disease, NIH, Bethesda, MD, USA.
Ryan HobbsKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Li-Ka LiuLaboratory of Cell and Molecular Biology; National Institute of Diabetes and Digestive and Kidney Disease, NIH, Bethesda, MD, USA.
Ping-Hsien LeeCenter for Cell-Based Therapy, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-6491-2410
Patricia OutedaDepartment of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA.
Fang ZhouKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA.
Nicholas P RestifoCenter for Cell-Based Therapy, National Cancer Institute, NIH, Bethesda, MD, USA.
Terry WatnickDepartment of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA.
Haruna KawanoDepartment of Urology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Shigeo HorieDepartment of Urology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
William PrinzLaboratory of Cell and Molecular Biology; National Institute of Diabetes and Digestive and Kidney Disease, NIH, Bethesda, MD, USA.
Hong XuLaboratory of Molecular Genetics; National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.
Luis F MenezesKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA. luis.menezes@nih.gov.ORCID 0000-0003-2225-168X
Gregory G GerminoKidney Disease Branch; National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health (NIH), Bethesda, MD, USA. germinogg@mail.nih.gov.
National Institutes of Health · USNational Institute of Diabetes and Digestive and Kidney Diseases · USJuntendo University · JPLaboratory of Molecular Genetics · PLNational Cancer Institute · USUniversity of Maryland, Baltimore · USThe University of Tokyo · JP
Funding
Mitochondrial DNA inheritance in DrosophilaZIAHL006153 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI XU, HONG · 2012 to 2025
$26.5MBuilding on the success of the adoptive immunotherapy of cancerZIABC010763 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ROSENBERG, STEVEN · 2009 to 2020
$25.0MThe role of PKD proteins in regulating tubular morphologyZIADK075042 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GERMINO, GREGORY · 2010 to 2025
$23.3MResearch BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2010 to 2019
$11.1MIntracellular Lipid Trafficking and Organelle BiogenesisZIADK060004 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PRINZ, WILLIAM · 2009 to 2022
$8.5MBiogenesis of the endoplasmic reticulumZIADK060105 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PRINZ, WILLIAM · 2009 to 2022
$8.5MComprehensive Analysis of Polycystin Related Endothelial Cell Signaling PathwaysR01DK095036 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2012 to 2021
$2.3MIntramural NIH HHS ZIA BC010763Intramural NIH HHS ZIA DK060004Intramural NIH HHS ZIA DK075042Intramural NIH HHS ZIA HL006153NIDDK NIH HHS P30 DK090868NIDDK NIH HHS R01 DK095036
Abstract
Recent studies have reported intrinsic metabolic reprogramming in Pkd1 knock-out cells, implicating dysregulated cellular metabolism in the pathogenesis of polycystic kidney disease. However, the exact nature of the metabolic changes and their underlying cause remains controversial. We show herein that Pkd1
Indexed as
KidneyMitochondriaProteolysisAgedAnimalsAnimals, Genetically ModifiedDogsDrosophila melanogasterEmbryo, MammalianEpithelial CellsFatty AcidsGene Knockdown TechniquesHumansMadin Darby Canine Kidney CellsMaleMiceFatty AcidsMitochondrial ProteinsTRPP Cation Channels
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