ArticleNPJ schizophrenia2018
Sleep endophenotypes of schizophrenia: slow waves and sleep spindles in unaffected first-degree relatives.
Article in NPJ schizophrenia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Sleep and wake markers of thalamocortical functioning in early-course psychosis and first-degree relatives.Schizophrenia (Heidelberg, Germany) · 2026Article
- The Interplay Between Sleep and Mental Health: A Genetic Perspective.Biological psychiatry · 2025Review
- Sleep Spindle Abnormalities as Neurophysiological Biomarkers of Schizophrenia Spectrum Disorders: From Cellular Mechanisms and Neural Circuits to Clinical Implications.Biological psychiatry · 2025Review
- Infant sleep EEG features at 4 months as biomarkers of neurodevelopment at 18 months.Pediatric research · 2025Article
- Sleep Spindle Abnormalities in Preschool Children With Autism Spectrum Disability: Insights From Nap Polysomnography.Autism research : official journal of the International Society for Autism Research · 2025Article
- Association of insomnia with suicide attempts in Chinese chronic schizophrenia patients with and without autistic symptoms.BMC psychiatry · 2025Article
- Age-Related Changes in Sleep and Its Implications for Cognitive Decline in Aging Persons With Schizophrenia: A Critical Review.Schizophrenia bulletin · 2025Review
- Does fragmented sleep mediate the relationship between deficits in sleep spindles and memory consolidation in schizophrenia?Sleep advances : a journal of the Sleep Research Society · 2025Article
- Reducing brain kynurenic acid synthesis precludes kynurenine-induced sleep disturbances.Journal of sleep research · 2024Article
- Proof-of-concept evidence for high-density EEG investigation of sleep slow wave traveling in First-Episode Psychosis.Scientific reports · 2024Article
- A Thalamocortical Perspective on Sleep Spindle Alterations in Neurodevelopmental Disorders.Current sleep medicine reports · 2024Review
- From macro to micro: slow-wave sleep and its pivotal health implications.Frontiers in sleep · 2024Review
- NREM sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives.bioRxiv : the preprint server for biology · 2023Article
- Sleep spindles, stress and PTSD: The state of the science and future directions.Neurobiology of stress · 2023Article
- Sleep spindles across youth affected by schizophrenia or anti-Frontiers in psychiatry · 2023Article
- Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.Frontiers in neuroanatomy · 2023Review
- Alterations in TRN-anterodorsal thalamocortical circuits affect sleep architecture and homeostatic processes in oxidative stress vulnerable GclmMolecular psychiatry · 2022Article
- Association of polygenic risk for schizophrenia with fast sleep spindle density depends on pro-cognitive variants.European archives of psychiatry and clinical neuroscience · 2022Article
- Article
- Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.The American journal of psychiatry · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep spindles and slow waves are the main brain oscillations occurring in non-REM sleep. Several lines of evidence suggest that spindles are initiated within the thalamus, whereas slow waves are generated and modulated in the cortex. A decrease in sleep spindle activity has been described in Schizophrenia (SCZ), including chronic, early course, and early onset patients. In contrast, slow waves have been inconsistently found to be reduced in SCZ, possibly due to confounds like duration of illness and antipsychotic medication exposure. Nontheless, the implication of sleep spindles and slow waves in the neurobiology of SCZ and related disorders, including their heritability, remains largely unknown. Unaffected first-degree relatives (FDRs) share a similar genetic background and several neurophysiological and cognitive deficits with SCZ patients, and allow testing whether some of these measures are candidate endophenotypes. In this study, we performed sleep high-density EEG recordings to characterise the spatiotemporal features of sleep spindles and slow waves in FDRs of SCZ probands and healthy subjects (HS) with no family history of SCZ. We found a significant reduction of integrated spindle activity (ISAs) in FDRs relative to HS, whereas spindle density and spindle duration were not different between groups. FDRs also had decreased slow wave amplitude and slopes. Altogether, our results suggest that ISAs deficits might represent a candidate endophenotype for SCZ. Furthermore, given the slow wave deficits observed in FDRs, we propose that disrupted cortical synchronisation increases the risk for SCZ, but thalamic dysfunction is necessary for the disorder to fully develop.
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