Evidence map›Paper›PMID 29426751›Full record

ArticleThe journal of allergy and clinical immunology. In practice

The Dietary Inflammatory Index and Current Wheeze Among Children and Adults in the United States.

Yueh-Ying Han, Erick Forno, Nitin Shivappa, Michael D Wirth, James R Hébert, Juan C Celedón

Open access · greenAbstract read
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
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  4. Article
  5. Review
  6. The Role of Lipid Metabolism Disorders in Rhinitis and Asthma.Combinatorial chemistry & high throughput screening · 2026
    Review
  7. Development of the Respiratory System During Adolescence.Advances in experimental medicine and biology · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pa.
Erick FornoDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pa.
Nitin ShivappaDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC; Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC; Connecting Health Innovations, Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.
Michael D WirthDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC; Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC; Connecting Health Innovations, Cancer Prevention and Control Program, University of South Carolina, Columbia, SC; College of Nursing, University of South Carolina, Columbia, SC.
James R HébertDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC; Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, Columbia, SC; Connecting Health Innovations, Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pa. Electronic address: juan.celedon@chp.edu.
Connecting Health Innovations (United States) · USUniversity of Pittsburgh · USChildren's Hospital of Pittsburgh · USUniversity of South Carolina · US

Funding

Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Vitamin D to Prevent Severe Asthma Exacerbations in High-Risk Children - CCCU01HL119952 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2015 to 2018
$2.9M
Developing the Dietary Inflammatory Index for Clinical ApplicationR44DK103377 · NIDDK · CONNECTING HEALTH INNOVATIONS, LLC · PI SHIVAPPA, NITIN, WIRTH, MICHAEL DAVID · 2014 to 2016
$1.8M
Exposure to violence, epigenetic variation, and asthma in Puerto Rican childrenR01MD011764 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2017 to 2020
$1.3M
Obesity and Asthma Subphenotypes and Underlying Genetic and Genomic PathwaysK08HL125666 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2015 to 2018
$589k
NHLBI NIH HHS K08 HL125666NHLBI NIH HHS R01 HL117191NHLBI NIH HHS U01 HL119952NIDDK NIH HHS R44 DK103377NIMHD NIH HHS R01 MD011764
6 · The paper itself

Abstract

backgroundA proinflammatory diet may increase allergic airway inflammation by affecting innate and adaptive immune responses.

objectiveIn this study, we examine the relation between the diet's inflammatory potential, measured by the Dietary Inflammatory Index (DII), and current asthma, current wheeze, and lung function in U.S. children and adults.

methodsWe analyzed data from 8,175 children (aged 6-17 years) and 22,294 adults (aged 18-79 years) who participated in the 2007-2012 National Health and Nutrition Examination Survey. The DII was calculated by nutrient intake based on 24-hour dietary recalls, and normalized as per 1,000 calories of food consumed to account for total energy intake. Multivariable regression models were used for the analysis of the DII and current asthma, current wheeze, and lung function measures.

resultsHigher DII (a proinflammatory diet) was associated with current wheeze among adults (eg, odds ratio [OR] for quartile 4 vs 1, OR = 1.41, 95% confidence interval [CI] = 1.17-1.70; P

conclusionsOur findings suggest that a proinflammatory diet, assessed by the DII, increases the odds of current wheeze in adults and children with allergic (atopic) wheeze. These results further support testing dietary interventions as part of the management of asthma.

Indexed as

DietAdolescentAdultAgedAsthmaChildFemaleHumansInflammationMaleMiddle AgedNitric OxideNutrition SurveysRespiratory Function TestsRespiratory SoundsUnited StatesNitric OxideAsthmaDietary Inflammatory IndexLung functionNHANESWheezing

Identifiers

PMID29426751
PMCPMC5948124
OpenAlexW2787182618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.