Evidence map›Paper›PMID 29426701›Full record

ArticleImmunity2018

A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.

Murad R Mamedov, Anja Scholzen, Ramesh V Nair, Katherine Cumnock, Justin A Kenkel, Jose Henrique M Oliveira, Damian L Trujillo, Naresha Saligrama, Yue Zhang, Florian Rubelt and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Malaria: past, present, and future.Signal transduction and targeted therapy · 2025
    Review
  6. Article
  7. Article
  8. IL-23 induces CLEC5AJournal of autoimmunity · 2024
    Article
  9. Article
  10. Innate immune memory in inflammatory arthritis.Nature reviews. Rheumatology · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Development of γδ T Cells: Soldiers on the Front Lines of Immune Battles.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  16. Review
  17. Article
  18. RNA mProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  19. CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Murad R MamedovProgram in Immunology, Stanford University, Stanford, CA 94305, USA; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA.
Anja ScholzenDepartment of Medical Microbiology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands; Innatoss Laboratories B.V., 5349 AB Oss, the Netherlands.
Ramesh V NairDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Katherine CumnockDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Justin A KenkelDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Jose Henrique M OliveiraDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, Brazil.
Damian L TrujilloDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Aduro Biotech, Inc., Berkeley, CA 94710, USA.
Naresha SaligramaDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Yue ZhangDepartment of Genetics, Stanford University, Stanford, CA 94305, USA; Genetics Bioinformatics Service Center, Stanford University, Stanford, CA 94305, USA.
Florian RubeltInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
David S SchneiderDepartment of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Yueh-Hsiu ChienProgram in Immunology, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Robert W SauerweinDepartment of Medical Microbiology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: mmdavis@stanford.edu.
Stanford University · USRadboud University Nijmegen · NLHoward Hughes Medical Institute · US

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
Howard Hughes Medical InstituteNIAID NIH HHS T32 AI007290NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Despite evidence that γδ T cells play an important role during malaria, their precise role remains unclear. During murine malaria induced by Plasmodium chabaudi infection and in human P. falciparum infection, we found that γδ T cells expanded rapidly after resolution of acute parasitemia, in contrast to αβ T cells that expanded at the acute stage and then declined. Single-cell sequencing showed that TRAV15N-1 (Vδ6.3) γδ T cells were clonally expanded in mice and had convergent complementarity-determining region 3 sequences. These γδ T cells expressed specific cytokines, M-CSF, CCL5, CCL3, which are known to act on myeloid cells, indicating that this γδ T cell subset might have distinct functions. Both γδ T cells and M-CSF were necessary for preventing parasitemic recurrence. These findings point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.

Indexed as

AnimalsFemaleHumansLymphocyte ActivationMacrophage Colony-Stimulating FactorMalariaMiceParasitemiaReceptors, Antigen, T-Cell, gamma-deltaRecurrenceT-Lymphocyte SubsetsMacrophage Colony-Stimulating FactorReceptors, Antigen, T-Cell, gamma-deltagamma-delta T cellsmalariaM-CSFPlasmodium chabaudiPlasmodium falciparumrecrudescenceTRAV15N-1TγδMVδ6.3γδ T cells

Identifiers

PMID29426701
PMCPMC5956914
OpenAlexW2786804236

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.