ArticleRadiation oncology (London, England)2018
Optimizing the prescription isodose level in stereotactic volumetric-modulated arc radiotherapy of lung lesions as a potential for dose de-escalation.
Article in Radiation oncology (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- The tumor core boost study: A feasibility study of radical dose escalation to the central part of large tumors with an integrated boost in the palliative treatment setting.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023Trial
- Comparison of dosimetric parameters and delivery accuracy between conformal radiotherapy-intensity modulated radiotherapy-combined and intensity-modulated radiotherapy planning for central lung cancer patients receiving stereotactic body radiotherapy.Quantitative imaging in medicine and surgery · 2026Article
- Dosimetric comparison of scanned proton therapy and volumetric modulated arc therapy in isodose-prescribed stereotactic body radiotherapy for lung cancer.Journal of radiation research · 2026Article
- Comprehensive plan quality assessment of simplified volumetric-modulated arc therapy for lung stereotactic body radiotherapy.Radiological physics and technology · 2025Article
- Article
- Impact of prescription isodose level and collimator selection on dose homogeneity and plan quality in robotic radiosurgery.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022Article
- Verification of an optimizer algorithm by the beam delivery evaluation of intensity-modulated arc therapy plans.Radiology and oncology · 2021Article
- Cleaning the dose falloff in lung SBRT plan.Journal of applied clinical medical physics · 2021Article
- A physically meaningful relationship between R50% and PTV surface area in lung SBRT.Journal of applied clinical medical physics · 2020Article
- Automated planning through robust templates and multicriterial optimization for lung VMAT SBRT of lung lesions.Journal of applied clinical medical physics · 2020Article
- Spatially fractionated radiotherapy (SFRT) targeting the hypoxic tumor segment for the intentional induction of non-targeted effects: AnTechnical innovations & patient support in radiation oncology · 2020Article
- Optimal prescription isodose line in SBRT for lung tumor treatment with volumetric-modulated arc therapy.Journal of radiosurgery and SBRT · 2020Article
- Selection of prescription isodose line for brain metastases treated with volumetric modulated arc radiotherapy.Journal of applied clinical medical physics · 2019Article
- Single fraction computed tomography-guided high-dose-rate brachytherapy or stereotactic body radiotherapy for primary and metastatic lung tumors?Journal of contemporary brachytherapy · 2018Article
- A study of minimum segment width parameter on VMAT plan quality, delivery accuracy, and efficiency for cervical cancer using Monaco TPS.Journal of applied clinical medical physics · 2018Article
- Non-coplanar VMAT combined with non-uniform dose prescription markedly reduces lung dose in breath-hold lung SBRT.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018Article
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5 authors.
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Abstract
backgroundTo derive and exploit the optimal prescription isodose level (PIL) in inverse optimization of volumetric modulated arc radiotherapy (VMAT) as a potential approach to dose de-escalation in stereotactic body radiotherapy for non-small cell lung carcinomas (NSCLC).
methodsFor ten patients, inverse Monte Carlo dose optimization was performed to cover 95% PTV by varying prescription isodose lines (PIL) at 60 to 80% and reference 85%. Subsequently, these were re-normalized to the median gross tumor volume dose (GTV-based prescription) to assess the impacts of PTV and normal tissue dose reduction.
resultsWith PTV-based prescription, GTV mean dose was much higher with the optimized PIL at 60% with significant reduction of normal lung receiving 30 to 10 Gy (V
conclusionsOptimizing the PIL with VMAT has notable advantage of improving the dosimetric quality of lung SBRT and offers the potential of dose de-escalation for surrounding tissues while increasing the GTV dose simultaneously. The clinical implication of re-normalizing plans from PTV-prescription at 60-70% to the GTV median dose requires further investigations.
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