Evidence map›Paper›PMID 29426347›Full record

ArticleReproductive health2018

Attitudes of sperm, egg and embryo donors and recipients towards genetic information and screening of donors.

David J Amor, Annabelle Kerr, Nandini Somanathan, Alison McEwen, Marianne Tome, Jan Hodgson, Sharon Lewis

Open access · goldAbstract read
In one paragraph

Article in Reproductive health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Mapping Ethical, Legal, and Social Implications (ELSI) of gamete donation.Journal of assisted reproduction and genetics · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. The use of expanded carrier screening of gamete donors.Human reproduction (Oxford, England) · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David J AmorMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia. david.amor@mcri.edu.au.ORCID http://orcid.org/0000-0001-7191-8511
Annabelle KerrMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
Nandini SomanathanMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
Alison McEwenGraduate School of Health, University of Technology, Sydney, Australia.
Marianne TomeMelbourne IVF, East Melbourne, Australia.
Jan HodgsonMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
Sharon LewisMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.
Royal Children's Hospital · AUMyer Foundation · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGamete and embryo donors undergo genetic screening procedures in order to maximise the health of donor-conceived offspring. In the era of genomic medicine, expanded genetic screening may be offered to donors for the purpose of avoiding transmission of harmful genetic mutations. The objective of this study was to explore the attitudes of donors and recipients toward the expanded genetic screening of donors.

methodsQualitative interview study with thematic analysis, undertaken in a tertiary fertility centre. Semi-structured in-depth qualitative interviews were conducted with eleven recipients and nine donors from three different cohorts (sperm, egg and embryo donors/recipients).

resultsDonors and recipients acknowledged the importance of genetic information and were comfortable with the existing level of genetic screening of donors. Recipients recognised some potential benefits of expanded genetic screening of donors; however both recipients and donors were apprehensive about extended genomic technologies, with concerns about how this information would be used and the ethics of genetic selectivity.

conclusionParticipants in donor programs support some level of genetic screening of donors, but are wary of expanding genetic screening beyond current levels.

Indexed as

Attitude to HealthOocyte DonationSpermatozoaEmbryo, MammalianFamily CharacteristicsFemaleGenetic PrivacyGenetic TestingHumansInsemination, Artificial, HeterologousMaleTissue DonorsAssisted reproductionDonor conceptionDonor spermGenetic screening

Identifiers

PMID29426347
PMCPMC5807856
OpenAlexW2797879566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.