Evidence map›Paper›PMID 29426337›Full record

ReviewRetrovirology2018

Non-coding RNAs and retroviruses.

Xu Zhang, Xiancai Ma, Shuliang Jing, Hui Zhang, Yijun Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Retrovirology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements.Mammalian genome : official journal of the International Mammalian Genome Society · 2021
    Article
  11. Non-coding RNAS and colorectal cancer liver metastasis.Molecular and cellular biochemistry · 2020
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xu ZhangInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Xiancai MaInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Shuliang JingInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China.
Hui ZhangInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080, China. zhangh92@mail.sysu.edu.cn.
Yijun ZhangSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. yi-jun.zhang@yale.edu.ORCID 0000-0001-7971-2200
Sun Yat-sen University · CNYale University · US

Funding

Role of non-coding RNA in establishing and maintaining HIV latencyR01AI120204 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KARN, JONATHAN · 2015 to 2017
$594k
Guangdong Innovative Research Team Program 2009010058Joint-innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou, China 201508020256National Natural Science Foundation of China 81730060National Natural Science Foundation of China (NSFC-NIH project) 81561128007NIAID NIH HHS R01 AI120204
6 · The paper itself

Abstract

Retroviruses can cause severe diseases such as cancer and acquired immunodeficiency syndrome. A unique feature in the life cycle of retroviruses is that their RNA genome is reverse transcribed into double-stranded DNA, which then integrates into the host genome to exploit the host machinery for their benefits. The metazoan genome encodes numerous non-coding RNAs (ncRNA), which act as key regulators in essential cellular processes such as antiviral response. The development of next-generation sequencing technology has greatly accelerated the detection of ncRNAs from viruses and their hosts. ncRNAs have been shown to play important roles in the retroviral life cycle and virus-host interactions. Here, we review recent advances in ncRNA studies with special focus on those have changed our understanding of retroviruses or provided novel strategies to treat retrovirus-related diseases. Many ncRNAs such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are involved in the late phase of the retroviral life cycle. However, their roles in the early phase of viral replication merit further investigations.

Indexed as

Gene Expression Regulation, ViralHost-Pathogen InteractionsHumansMicroRNAsRetroviridaeRetroviridae InfectionsRNA InterferenceRNA, Long NoncodingRNA, UntranslatedVirus LatencyMicroRNAsRNA, Long NoncodingRNA, UntranslatedLong non-coding RNAMicroRNANon-coding RNARetrovirusesViral life cycleVirus latency

Identifiers

PMID29426337
PMCPMC5807749
OpenAlexW2790852272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.