ArticleArthritis & rheumatology (Hoboken, N.J.)2018
Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Identification and evaluation of 41 risk loci for juvenile idiopathic arthritis informs precision medicine: mechanistic implications of DNA topology and an HLA-A*02:01-ERAP2 interaction.medRxiv : the preprint server for health sciences · 2026Article
- Temporo-mandibular joint alterations in juvenile idiopathic arthritis and young-onset inflammatory arthropathies: a magnetic resonance imaging study with ultrasound comparison.Pediatric rheumatology online journal · 2026Article
- Targeted delivery of curcumin based on nanocarriers: potential therapeutic strategies for noninfectious arthritis.Inflammopharmacology · 2026Review
- Methotrexate Therapy in Juvenile Idiopathic Arthritis: No Clinically Relevant Pulmonary Impairment but Frequent Transient Liver Enzyme Elevations in a Longitudinal Single-Center Pediatric Cohort of 274 Children Over 30 Years.ACR open rheumatology · 2026Article
- Serum ferritin in children with juvenile idiopathic arthritis: a promising subtype-specific marker of disease activity.European journal of pediatrics · 2025Article
- [Juvenile idiopathic arthritis-Diagnosis and management].Zeitschrift fur Rheumatologie · 2025Review
- Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence.Current environmental health reports · 2024Review
- Sex differences in musculoskeletal injury and disease risks across the lifespan: Are there unique subsets of females at higher risk than males for these conditions at distinct stages of the life cycle?Frontiers in physiology · 2023Review
- Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Implications of Evolving Disease Classification for Drug Approval in Juvenile Idiopathic Arthritis.Paediatric drugs · 2022Article
- [Polyarticular juvenile idiopathic arthritis and rheumatoid arthritis : Common features and differences].Zeitschrift fur Rheumatologie · 2022Review
- B Cells on the Stage of Inflammation in Juvenile Idiopathic Arthritis: Leading or Supporting Actors in Disease Pathogenesis?Frontiers in medicine · 2022Review
- JAK inhibitors: a potential treatment for JDM in the context of the role of interferon-driven pathology.Pediatric rheumatology online journal · 2021Review
- Biological classification of childhood arthritis: roadmap to a molecular nomenclature.Nature reviews. Rheumatology · 2021Review
- STING-Mediated Lung Inflammation and Beyond.Journal of clinical immunology · 2021Review
- Efficacy and Safety of Abatacept, Adalimumab, and Etanercept in Pediatric Patients With Juvenile Idiopathic Arthritis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Review
- Review
- MicroRNA-125b regulates Th17/Treg cell differentiation and is associated with juvenile idiopathic arthritis.World journal of pediatrics : WJP · 2020Article
- Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease.Frontiers in immunology · 2020Review
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Authors and funding
31 authors at 18 institutions in 5 countries.
Funding
Abstract
objectiveJuvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)-positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF-positive polyarticular JIA with those of RA and selected other JIA categories, to more fully understand the pathophysiologic relationships of inflammatory arthropathies.
methodsPatients with RF-positive polyarticular JIA (n = 340) and controls (n = 14,412) were genotyped using the Immunochip array. Single-nucleotide polymorphisms were tested for association using a logistic regression model adjusting for admixture proportions. We calculated weighted genetic risk scores (wGRS) of reported RA and JIA risk loci, and we compared the ability of these wGRS to predict RF-positive polyarticular JIA.
resultsAs expected, the HLA region was strongly associated with RF-positive polyarticular JIA (P = 5.51 × 10
conclusionRF-positive polyarticular JIA is genetically more similar to adult RA than to the most common JIA categories and thus appears to be a childhood-onset presentation of autoantibody-positive RA. These findings suggest common disease mechanisms, which could lead to novel therapeutic targets and shared treatment strategies.
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