ArticleOsteoarthritis and cartilage2018
MRI UTE-T2* profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction.
Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are Altered Knee Joint Biomechanics Associated with Future Post-Traumatic Osteoarthritis Outcomes? A Systematic Review and Meta-Analysis of Longitudinal Studies.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Early MRI-based quantitative outcomes are associated with a positive functional performance trajectory from 6 to 24 months post-ACL surgery.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Trial
- Clinical applications of UTE-T2* in knee MRI.Skeletal radiology · 2026Review
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Posttraumatic osteoarthritis after athletic knee injury: A narrative review of diagnostic imaging strategies.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- Efficacy of a Squat Visual Biofeedback Program After ACL Reconstruction: Protocol for a Prospective, Parallel, Randomized Controlled Trial.International journal of sports physical therapy · 2025Article
- Quantitative Evaluation of Knee Cartilage in Professional Martial Arts Athletes Using T2 Mapping: A Comparative Study.Journal of athletic training · 2024Article
- T1ρ and T2* Measurements in Small and Knee-Sized Magnetic Resonance Imaging Phantoms: Effect of Phantom Size and Position Relative to Isocenter.Osteoarthritis imaging · 2023Article
- LigaNET: A multi-modal deep learning approach to predict the risk of subsequent anterior cruciate ligament injury after surgery.medRxiv : the preprint server for health sciences · 2023Article
- Patellofemoral joint loading and early osteoarthritis after ACL reconstruction.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Ultrashort echo time magnetization transfer imaging of knee cartilage and meniscus after long-distance running.European radiology · 2023Article
- Predicting anterior cruciate ligament failure load with TScientific reports · 2023Article
- Automated segmentation of the healed anterior cruciate ligament from TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Reproducibility and postacquisition correction methods for quantitative magnetic resonance imaging of the anterior cruciate ligament (ACL).Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Knee Kinematic Patterns and Early Cartilage Lesion Characteristics in Patients with Anterior Cruciate Ligament Reconstruction.Journal of clinical medicine · 2022Article
- UTE-T2* versus conventional T2* mapping to assess posterior cruciate ligament ultrastructure and integrity-anQuantitative imaging in medicine and surgery · 2022Article
- Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review.Frontiers in endocrinology · 2022Review
- A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Article
- Micro- and Macroscale Assessment of Posterior Cruciate Ligament Functionality Based on Advanced MRI Techniques.Diagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveQuantitative magnetic resonance imaging (MRI) ultrashort echo time (UTE) T2* is sensitive to cartilage deep tissue matrix changes after anterior cruciate ligament reconstruction (ACLR). This study was performed to determine whether UTE-T2* profile analysis is a useful clinical metric for assessing cartilage matrix degeneration. This work tests the hypotheses that UTE-T2* depthwise rates of change (profile slopes) correlate with clinical outcome metrics of walking mechanics and patient reported outcomes (PRO) in patients 2 years after ACLR.
designThirty-six patients 2 years after ACLR completed knee MRI, gait analysis, and PRO. UTE-T2* maps were generated from MRI images and depthwise UTE-T2* profiles were calculated for weight-bearing cartilage in the medial compartment. UTE-T2* profiles from 14 uninjured subjects provided reference values. UTE-T2* profile characteristics, including several different measures of profile slope, were tested for correlation to kinetic and kinematic measures of gait and also to PRO.
resultsDecreasing UTE-T2* profile slopes in ACLR knees moderately correlated with increasing knee adduction moments (r = 0.41, P < 0.015), greater external tibial rotation (r = 0.44, P = 0.007), and moderately negatively correlated with PRO (r = -0.36, P = 0.032). UTE-T2* profiles from both ACLR and contralateral knees of ACLR subjects differed from that of uninjured controls (P < 0.015).
conclusionsThe results of this study suggest that decreasing UTE-T2* profile slopes reflect cartilage deep tissue collagen matrix disruption in a population at increased risk for knee osteoarthritis (OA). That UTE-T2* profiles were associated with mechanical and patient reported measures of clinical outcomes support further study into a potential mechanistic relationship between these factors and OA development.
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Registered trials
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