Evidence map›Paper›PMID 29426005›Full record

ArticleOsteoarthritis and cartilage2018

Harmonising measures of knee and hip osteoarthritis in population-based cohort studies: an international study.

K M Leyland, L S Gates, M Nevitt, D Felson, S M Bierma-Zeinstra, P G Conaghan, L Engebretsen, M Hochberg, D J Hunter, G Jones and 11 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 8 countries.

K M LeylandNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
L S GatesNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK; Faculty of Health Sciences, University of Southampton, Southampton, UK. Electronic address: l.Gates@soton.ac.uk.
M NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
D FelsonClinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA.
S M Bierma-ZeinstraDepartment of General Practice, Erasmus University Medical Centre, Rotterdam, The Netherlands; Department of Orthopaedics, Erasmus University Medical Centre, Rotterdam, The Netherlands.
P G ConaghanLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK.
L EngebretsenDepartment of Orthopaedic Surgery, Oslo University Hospital, Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, Oslo, Norway.
M HochbergUniversity of Maryland School of Medicine, Baltimore, USA.
D J HunterInstitute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, St Leonards, Sydney, Australia.
G JonesMenzies Research Institute Tasmania, University of Tasmania, Hobart, Australia.
J M JordanThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
A JudgeNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK.
L S LohmanderLund University, Department of Clinical Sciences Lund, Orthopaedics, Lund, Sweden.
E M RoosInstitute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
M T Sanchez-SantosNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK.
N YoshimuraDepartment of Joint Disease Research, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
J B J van MeursDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
M E BattCentre for Sports Medicine, Nottingham University Hospitals, Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Nottingham, UK.
J NewtonNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK.
C CooperNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK; Faculty of Health Sciences, University of Southampton, Southampton, UK.
N K ArdenNIHR Musculoskeletal Biomedical Research Unit, Arthritis Research UK Centre for Sport, Exercise, and Osteoarthritis, University of Oxford, Oxford, UK; Faculty of Health Sciences, University of Southampton, Southampton, UK.
University of Oxford · GBErasmus MC · NLArthritis UK · GBBoston University · USLund University · SEOslo University Hospital · NOThe University of Sydney · AUThe University of Tokyo · JPUniversity of Bristol · GBUniversity of California, San Francisco · USUniversity of Leeds · GBUniversity of Maryland, Baltimore · USUniversity of North Carolina at Chapel Hill · USUniversity of Southern Denmark · DKUniversity of Tasmania · AU

Funding

Johnston County Osteoarthritis Project: Arthritis, Disability, and Other Chronic DiseasesU01DP006266 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NELSON, AMANDA E · 2016 to 2020
$3.8M
Arthritis Research UK 20194Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1NCCDPHP CDC HHS U01 DP006266Versus Arthritis 21509
6 · The paper itself

Abstract

objectivePopulation-based osteoarthritis (OA) cohorts provide vital data on risk factors and outcomes of OA, however the methods to define OA vary between cohorts. We aimed to provide recommendations for combining knee and hip OA data in extant and future population cohort studies, in order to facilitate informative individual participant level analyses.

methodInternational OA experts met to make recommendations on: 1) defining OA by X-ray and/or pain; 2) compare The National Health and Nutrition Examination Survey (NHANES)-type OA pain questions; 3) the comparability of the Western Ontario & McMaster Universities Osteoarthritis Index (WOMAC) scale to NHANES-type OA pain questions; 4) the best radiographic scoring method; 5) the usefulness of other OA outcome measures. Key issues were explored using new analyses in two population-based OA cohorts (Multicenter Osteoarthritis Study; MOST and Osteoarthritis Initiative OAI).

resultsOA should be defined by both symptoms and radiographs, with symptoms alone as a secondary definition. Kellgren and Lawrence (K/L) grade ≥2 should be used to define radiographic OA (ROA). The variable wording of pain questions can result in varying prevalence between 41.0% and 75.4%, however questions where the time anchor is similar have high sensitivity and specificity (91.2% and 89.9% respectively). A threshold of 3 on a 0-20 scale (95% CI 2.1, 3.9) in the WOMAC pain subscale demonstrated equivalence with the preferred NHANES-type question.

conclusionThis research provides recommendations, based on expert agreement, for harmonising and combining OA data in existing and future population-based cohorts.

Indexed as

Pain MeasurementAgedCanadaCohort StudiesConsensusDisability EvaluationDisease ProgressionFemaleFollow-Up StudiesHumansInternationalityMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, HipOsteoarthritis, KneeCohortDataEpidemiologyHarmonisationOsteoarthritis

Identifiers

PMID29426005
PMCPMC6010158
OpenAlexW2786887452

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.