Evidence map›Paper›PMID 29425770›Full record

ReviewAdvanced drug delivery reviews2018

Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair.

Timothy J Keane, Christine-Maria Horejs, Molly M Stevens

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
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  13. Liposomal Delivery of a BiotechnologicalAntioxidants (Basel, Switzerland) · 2025
    Article
  14. [Research progress on collagen secretion mechanisms in scarring].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Timothy J KeaneDepartment of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Christine-Maria HorejsDepartment of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, Stockholm 17177, Sweden.
Molly M StevensDepartment of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Department of Bioengineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Institute of Biomedical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, UK; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles väg 2, Stockholm 17177, Sweden. Electronic address: m.stevens@imperial.ac.uk.
Imperial College London · GBKarolinska Institutet · SE

Funding

Medical Research Council MR/K026682/1Medical Research Council MR/L012677/1
6 · The paper itself

Abstract

All vertebrates possess mechanisms to restore damaged tissues with outcomes ranging from regeneration to scarring. Unfortunately, the mammalian response to tissue injury most often culminates in scar formation. Accounting for nearly 45% of deaths in the developed world, fibrosis is a process that stands diametrically opposed to functional tissue regeneration. Strategies to improve wound healing outcomes therefore require methods to limit fibrosis. Wound healing is guided by precise spatiotemporal deposition and remodelling of the extracellular matrix (ECM). The ECM, comprising the non-cellular component of tissues, is a signalling depot that is differentially regulated in scarring and regenerative healing. This Review focuses on the importance of the native matrix components during mammalian wound healing alongside a comparison to scar-free healing and then presents an overview of matrix-based strategies that attempt to exploit the role of the ECM to improve wound healing outcomes.

Indexed as

Wound HealingAnimalsCicatrixExtracellular MatrixHumansInflammationExtracellular matrix (ECM)FibrosisTissue engineeringWound healing

Identifiers

PMID29425770
PMCPMC6372066
OpenAlexW2791311190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.