ArticleReproductive toxicology (Elmsford, N.Y.)2018
A utilitarian comparison of two alcohol use biomarkers with self-reported drinking history collected in antenatal clinics.
Article in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Assessment of substance exposures in nail clipping samples: A systematic review.Drug and alcohol dependence · 2024Pooled it
- Maternal gut and vaginal microbiota, alcohol use during pregnancy, and infant fetal alcohol spectrum disorder diagnosis in a South African cohort.medRxiv : the preprint server for health sciences · 2026Article
- Prenatal Substance Exposure and Birth Weight: Findings From the HEALthy Brain and Child Development Study.Pediatrics · 2026Observational
- Does paternal alcohol consumption affect the severity of traits of fetal alcohol spectrum disorders?Alcohol, clinical & experimental research · 2025Article
- Clinical Features of Typically Developing Children with and without Prenatal Alcohol Exposure.The Journal of pediatrics · 2025Article
- Maternal and paternal risk factors associated with diagnoses within the continuum of fetal alcohol spectrum disorders in the USA: Proximal and distal influences.Alcohol, clinical & experimental research · 2025Article
- Contribution of ferritin and zinc to adverse infant outcomes among pregnancies with prenatal alcohol exposure in South Africa.Reproductive toxicology (Elmsford, N.Y.) · 2024Article
- Perception of pregnant individuals, health providers and decision makers on interventions to cease substance consumption during pregnancy: a qualitative study.BMC public health · 2024Article
- Maternal risk factors for fetal alcohol spectrum disorders: Distal variables.Alcohol, clinical & experimental research · 2024Article
- Validity of prenatal AUDIT screening for alcohol disorders - a Nationwide Swedish register study.Upsala journal of medical sciences · 2024Article
- Multifaceted case management during pregnancy is associated with better child outcomes and less fetal alcohol syndrome.Annals of medicine · 2023Article
- Maternal dietary intake among alcohol-exposed pregnancies is linked to early infant physical outcomes in South Africa.Reproductive toxicology (Elmsford, N.Y.) · 2023Article
- Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders.BMC medical research methodology · 2023Article
- Community-based counselling programme for pregnant women with alcohol problems in Cape Town, South Africa: a qualitative study of the views of pregnant women and healthcare professionals.Frontiers in psychiatry · 2023Article
- Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools.Alcohol research : current reviews · 2023Review
- Assessing the sensitivity and specificity of phosphatidylethanol (PEth) cutoffs to identify alcohol exposed pregnancies.Current research in toxicology · 2023Article
- Characteristic physical traits of first-grade children in the United States with fetal alcohol spectrum disorders (FASD) and associated alcohol and drug exposures.American journal of medical genetics. Part A · 2022Article
- Associations Between Patterns of Alcohol Use and Viral Load Suppression Amongst Women Living with HIV in South Africa.AIDS and behavior · 2021Article
- Correlates of transitions from alcohol use to disorder diagnosed by DSM-5 in China.BMC psychiatry · 2021Article
- Gestational age and birth growth parameters as early predictors of fetal alcohol spectrum disorders.Alcoholism, clinical and experimental research · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAlcohol use is reported accurately among pregnant women in some populations.
methodsSelf-reported alcohol use via the AUDIT and 90-day recall for 193 women from antenatal clinics was compared to biomarker results: phosphatidylethanol (PEth) from bloodspots and ethyl glucuronide (EtG) in fingernails.
resultsAUDIT was positive for 67.9% of respondents, and 65.3% directly reported drinking. Individual biomarkers detected less drinking (PEth = 57.0%, EtG = 38.9%) than self-report. But 64.8% had drinking-positive values (>8 ng) on one or both biomarkers, which was not significantly different from self-report. Biomarkers indicated that 3.1% -6.8% of drinkers denied drinking. Combined biomarker sensitivity was 95% -80% and specificity 49% -76% for drinking in the previous 7-90 days. Combined biomarker results have their best yield (89.6%) and accuracy (78.8%) when measuring 90 day drinking.
conclusionsWomen reported their alcohol use accurately, and the combined use of PEth and EtG is supported.
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