ArticleInternational journal of cardiology2018
Efficacy of intramyocardial injection of Algisyl-LVR for the treatment of ischemic heart failure in swine.
Article in International journal of cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 32 citations in OpenAlex.
- Treatment of myocardial infarction via implantation of electroactive alginate/gelatin cardiac patch seeded with mesenchymal stem cells in a rat model.Drug delivery and translational research · 2026Article
- Bio-orthogonally double cross-linked alginate-gelatin hydrogels with tunable viscoelasticity for cardiac tissue engineering.Materials today. Bio · 2025Article
- Finite Element Modeling in Left Ventricular Cardiac Biomechanics: From Computational Tool to Clinical Practice.Bioengineering (Basel, Switzerland) · 2025Review
- Hydrogels in Cardiac Surgery: Versatile Platforms for Tissue Repair, Adhesion Prevention, and Localized Therapeutics.Gels (Basel, Switzerland) · 2025Review
- Reduced graphene oxide coated alginate scaffolds: potential for cardiac patch application.Biomaterials research · 2023Article
- Control of the post-infarct immune microenvironment through biotherapeutic and biomaterial-based approaches.Drug delivery and translational research · 2023Review
- Performance of xenogeneic pulmonary visceral pleura as bioprosthetic heart valve cusps in swine.Frontiers in cardiovascular medicine · 2023Article
- Left Ventricular Geometry and Angiogenesis Improvement in Rat Chronic Ischemic Cardiomyopathy following Injection of Encapsulated Mesenchymal Stem Cells.Cell journal · 2022Article
- Application of feed forward and recurrent neural networks in simulation of left ventricular mechanics.Scientific reports · 2020Article
- Intra-myocardial Delivery of a Novel Thermosensitive Hydrogel Inhibits Post-infarct Heart Failure After Degradation in Rat.Journal of cardiovascular translational research · 2020Article
- How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium.Acta biomaterialia · 2020Article
- In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy.Scientific reports · 2020Article
- Intra-myocardial alginate hydrogel injection acts as a left ventricular mid-wall constraint in swine.Acta biomaterialia · 2020Article
- Prediction of Left Ventricular Mechanics Using Machine Learning.Frontiers in physics · 2019Article
- Intramyocardial Injections to De-Stiffen the Heart: A Subject-Specific in Silico Approach.Molecular & cellular biomechanics : MCB · 2019Article
- Effect of intra-myocardial Algisyl-LVR™ injectates on fibre structure in porcine heart failure.Journal of the mechanical behavior of biomedical materials · 2018Article
- Construction and Validation of Subject-Specific Biventricular Finite-Element Models of Healthy and Failing Swine Hearts From High-Resolution DT-MRI.Frontiers in physiology · 2018Article
- Left Ventricular Wall Stress Is Sensitive Marker of Hypertrophic Cardiomyopathy With Preserved Ejection Fraction.Frontiers in physiology · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundProgressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac function. We sought to evaluate the efficacy of a biopolymer (Algisyl-LVR) to prevent left ventricular (LV) remodeling in a swine model of IHF.
methodsIHF was induced in 11 swine by occluding the marginal obtuse branches of the left circumflex artery. Eight weeks later, Algisyl-LVR was injected into the LV myocardial free wall in five of the 11 animals. Echocardiographic examinations were done every 2weeks for 16weeks.
resultsWithin eight weeks of treatment, the ejection fraction increased from 30.5%±7.7% to 42.4%±3.5% (treated group) vs. 37.3%±3.8% to 34.3%±2.9% (control), p<0.01. Stroke volume increased from 18.5±9.3mL to 41.3±13.3mL (treated group) vs. 25.4±2.3mL to 31.4±5.3mL (control), p<0.05. Wall thickness in end-diastole of the infarcted region changed from 0.69±0.06cm to 0.81±0.13cm (treated group) vs. 0.73±0.09cm to 0.68±0.11cm (control), p<0.05. Sphericity index remained almost unchanged after treatment, although differences were found at the end of the study between both groups (p<0.001). Average myofiber stress changed from 16.3±5.8kPa to 10.2±4.0kPa (treated group) vs. 15.2±4.8kPa to 17.9±5.6kPa (control), p<0.05.
conclusionsAlgisyl-LVR is an effective strategy that serves as a micro-LV assist device to reduce stress and hence prevent or reverse maladaptive cardiac remodeling caused by IHF in swine.
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