ArticleBiology of reproduction2018
Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice.
Article in Biology of reproduction, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- A systematic review and meta-analysis of the Endometriosis and Mental-Health Sequelae; The ELEMI Project.Women's health (London, England)Pooled it
- Altered Blood Pressure Reflexes in Women With Endometriosis.Hypertension (Dallas, Tex. : 1979) · 2025Trial
- Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach.Scientific reports · 2021Trial
- No difference in anxiety symptoms between women with unilateral and bilateral ovarian endometriosis: a prospective cross-sectional study.Annals of medicine · 2026Article
- Repeatedly occurring retrograde menstruation intensifies central sensitization driven by neuroinflammation in endometriosis models.The Journal of clinical investigation · 2026Article
- Behavioral attenuation of marble burying and digging mirrors evoked and non-evoked phenotypes in the endometriosis mouse model.Scientific reports · 2026Article
- Endometriosis as a Systemic and Complex Disease: Toward Phenotype-Based Classification and Personalized Therapy.International journal of molecular sciences · 2026Review
- Burrowing behavior is a potential non-invasive proxy for lesion development in a syngeneic murine model of endometriosis.BMC women's health · 2025Article
- Interventions for endometriosis-related pain and infertility: a protocol for systematic review and network meta-analysis.BMJ open · 2025Article
- Endometriosis, symptoms, and risk for depression and/or anxiety: a population-based retrospective study.BMC women's health · 2025Article
- C57BL/6J mice best recapitulate fibrosis and inflammatory pathophysiology in syngeneic mouse model of endometriosis.Scientific reports · 2025Article
- Disease Severity- and Hormonal Status-Dependent Alterations of EGF and MIF in the Serum of Endometriosis Patients.International journal of molecular sciences · 2025Article
- Impact of Therapeutic Interventions on Fear of Progression in Patients with Endometriosis.Journal of clinical medicine · 2025Article
- Predictors of anxiety in endometriosis patients.Archives of gynecology and obstetrics · 2025Article
- Dyspareunia and pelvic pain in women with chronic migraine: A retrospective, observational analysis.Headache · 2025Observational
- Unveiling the Mechanisms of Pain in Endometriosis: Comprehensive Analysis of Inflammatory Sensitization and Therapeutic Potential.International journal of molecular sciences · 2025Review
- Neuroinflammation is responsible for pain in endometriosis - targeting the JAK-STAT pathway and mast cell activation.Frontiers in immunology · 2025Review
- Increased incidence of uterine leiomyoma in young females with depression: An observational study.iScience · 2024Article
- Study on the Mechanisms of Glrα3 in Pain Sensitization of Endometriosis.International journal of molecular sciences · 2024Article
- Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread.International journal of molecular sciences · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Endometriosis is an estrogen-dependent inflammatory disorder among reproductive-aged women associated with pelvic pain, anxiety, and depression. Pain is characterized by central sensitization; however, it is not clear if endometriosis leads to increased pain perception or if women with the disease are more sensitive to pain, increasing the detection of endometriosis. Endometriosis was induced in mice and changes in behavior including pain perception, brain electrophysiology, and gene expression were characterized. Behavioral tests revealed that mice with endometriosis were more depressed, anxious and sensitive to pain compared to sham controls. Microarray analyses confirmed by qPCR identified differential gene expression in several regions of brain in mice with endometriosis. In these mice, genes such as Gpr88, Glra3 in insula, Chrnb4, Npas4 in the hippocampus, and Lcn2 in the amygdala were upregulated while Lct, Serpina3n (insula), and Nptx2 (amygdala) were downregulated. These genes are involved in anxiety, locomotion, and pain. Patch clamp recordings in the amygdala were altered in endometriosis mice demonstrating an effect of endometriosis on brain electrophysiology. Endometriosis induced pain sensitization, anxiety, and depression by modulating brain gene expression and electrophysiology; the effect of endometriosis on the brain may underlie pain sensitization and mood disorders reported in women with the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.