Evidence map›Paper›PMID 29425184›Full record

ArticleInternational journal of molecular sciences2018

Bioreducible Polymer Micelles Based on Acid-Degradable Poly(ethylene glycol)-poly(amino ketal) Enhance the Stromal Cell-Derived Factor-1α Gene Transfection Efficacy and Therapeutic Angiogenesis of Human Adipose-Derived Stem Cells.

Tae-Jin Lee, Min Suk Shim, Taekyung Yu, Kyunghee Choi, Dong-Ik Kim, Soo-Hong Lee, Suk Ho Bhang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Therapeutic Biomaterial Approaches to Alleviate Chronic Limb Threatening Ischemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Nano/Micro-Assisted Regenerative Medicine.International journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Tae-Jin LeeSchool of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea. eclatwiz@hotmail.com.ORCID 0000-0001-6091-542X
Min Suk ShimDivision of Bioengineering, Incheon National University, Incheon 406-772, Korea. msshim@inu.ac.kr.
Taekyung YuDepartment of Chemical Engineering, College of Engineering, Kyung Hee University, Youngin 17104, Korea. tkyu@khu.ac.kr.
Kyunghee ChoiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. kchoi@wustl.edu.
Dong-Ik KimDivision of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea. dikim@skku.edu.
Soo-Hong LeeDepartment of Biomedical Science, CHA University, Seongnam 463-400, Korea. soohong@cha.ac.kr.
Suk Ho BhangSchool of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea. sukhobhang@skku.edu.
Sungkyunkwan University · KRCHA University · KRIncheon National University · KRKyung Hee University · KRSamsung Medical Center · KRWashington University in St. Louis · US

Funding

Hemangioglast Development and RegulationR01HL055337 · NHLBI · WASHINGTON UNIVERSITY · PI CHOI, KYUNGHEE · 2001 to 2024
$9.1M
NHLBI NIH HHS R01 HL055337
6 · The paper itself

Abstract

Adipose-derived stem cells (ADSCs) have the potential to treat ischemic diseases. In general, ADSCs facilitate angiogenesis by secreting various pro-angiogenic growth factors. However, transplanted ADSCs have a low therapeutic efficacy in ischemic tissues due to their poor engraftment and low viability. Stromal cell-derived factor-1α (SDF-1α) improves the survival rate of stem cells transplanted into ischemic regions. In this study, we developed acid-degradable poly(ethylene glycol)-poly(amino ketal) (PEG-PAK)-based micelles for efficient intracellular delivery of

Indexed as

Gene Transfer TechniquesMicellesNeovascularization, PhysiologicAnimalsApoptosisBiodegradable PlasticsCells, CulturedChemokine CXCL12FemaleFibroblast Growth FactorsGenetic TherapyHindlimbHumansIschemiaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationBiodegradable PlasticsChemokine CXCL12Fibroblast Growth FactorsMicellesPolyethylene GlycolsVascular Endothelial Growth Factor Aangiogenesisbioreducible polymergene therapyhADSCsSDF-1α

Identifiers

PMID29425184
PMCPMC5855751
OpenAlexW2793228051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.