Evidence map›Paper›PMID 29425099›Full record

ArticleThe Journal of biological chemistry2018

Conserved cysteines in the finger domain of the epithelial Na

Brandon M Blobner, Xue-Ping Wang, Ossama B Kashlan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Epithelial NaComprehensive Physiology · 2024
    Review
  2. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  3. Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases.International journal of molecular sciences · 2021
    Review
  4. Article
  5. The epithelial NaThe Journal of biological chemistry · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brandon M BlobnerDepartments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261.
Xue-Ping WangDepartments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261.
Ossama B KashlanDepartments of Medicine, Renal-Electrolyte Division, Pittsburgh, Pennsylvania 15261; Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261. Electronic address: obk2@pitt.edu.

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Allosteric ENaC RegulationR01DK098204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2014 to 2018
$1.7M
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK098204NIDDK NIH HHS T32 DK061296
6 · The paper itself

Abstract

The epithelial Na

Indexed as

AnimalsCysteineEpithelial Sodium ChannelsHumansProtein DomainsXenopus laevisCysteineEpithelial Sodium Channelsallosteric regulationcysteine-mediated crosslinkingepithelial sodium channel (ENaC)protein conformationreactive oxygen species (ROS)

Identifiers

PMID29425099
PMCPMC5880152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.