ArticleEnvironmental health perspectives2018
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study.
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Association between the history of abortion and gestational diabetes mellitus: A meta-analysis.Endocrine · 2023Pooled it
- Environmental health influences in pregnancy and risk of gestational diabetes mellitus: a systematic review.BMC public health · 2022Pooled it
- The Association Between Cadmium Exposure and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.Frontiers in public health · 2021Pooled it
- Serum 25‑hydroxyvitamin D and dietary calcium intake interact in relation to blood cadmium in pregnant women: evidence from the NHANES survey.BMC pregnancy and childbirth · 2025Article
- 5'-Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation-Mediated PAK2 Upregulation to Promote Cadmium-Induced Breast Cancer Progression by Impairing Autophagic Flux.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cadmium Inhibits Proliferation of Human Bronchial Epithelial BEAS-2B Cells Through Inducing Ferroptosis via Targeted Regulation of the Nrf2/SLC7A11/GPX4 Pathway.International journal of molecular sciences · 2025Article
- Cadmium levels in maternal blood, placenta, and cord blood in relation to preeclampsia and fetal growth: a case-control study in China.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The impact of environmental and dietary exposure on gestational diabetes mellitus: a comprehensive review emphasizing the role of oxidative stress.Frontiers in endocrinology · 2025Review
- Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy.Environmental health : a global access science source · 2024Article
- Vitamin C Alleviates the Risk of Gestational Diabetes Mellitus Associated With Exposure to Metals.Journal of diabetes research · 2024Article
- Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy.Toxics · 2023Article
- Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort.Epigenetics · 2022Article
- Associations between Maternal Selenium Status and Cord Serum Vitamin D Levels: A Birth Cohort Study in Wuhan, China.Nutrients · 2022Article
- Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model.Endocrine · 2022Article
- The association between serum cadmium and diabetes in the general population: A cross-sectional study from NHANES (1999-2020).Frontiers in nutrition · 2022Article
- Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects.International journal of environmental research and public health · 2021Review
- Metal exposure and bone remodeling during pregnancy: Results from the PROGRESS cohort study.Environmental pollution (Barking, Essex : 1987) · 2021Article
- The Relationship Between Heavy Metal Exposure, Trace Element Level, and Monocyte to HDL Cholesterol Ratio with Gestational Diabetes Mellitus.Biological trace element research · 2021Article
- LncRNA-ENST00000446135 is a novel biomarker of cadmium toxicity in 16HBE cells, rats, and Cd-exposed workers and regulates DNA damage and repair.Toxicology research · 2020Article
- Urinary concentrations of environmental metals and associating factors in pregnant women.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have reported that cadmium (Cd) is associated with type 2 diabetes. However, little is known about Cd exposure and the risk of gestational diabetes mellitus (GDM).
objectiveWe examined the association between Cd body burden in early pregnancy and the risk of GDM.
methodsWe conducted a prospective study of 2,026 pregnant women from a single tertiary medical center between 2013 and 2016 in Wuhan, China. Cd body burden was reflected by Cd concentrations in urine samples collected between gestational weeks 8 and 14. GDM was diagnosed according to International Association of Diabetes and Pregnancy Study Groups Consensus Panel (IADPSG) recommendations.
resultsThe geometric mean of Cd concentrations in maternal urine of all pregnant women was 0.59μg/L. A total of 198 (9.8%) women were diagnosed with GDM. After adjustment for potential confounders, the risk ratios (RRs) of GDM were 1.04 (95% CI: 0.74, 1.44) for the middle tertile of Cd levels and 1.36 (95%: CI: 0.98, 1.90) for the top tertile compared with the bottom tertile. In addition, we found a significant interaction between fetal sex and maternal Cd levels on the risk of GDM (p for interaction=0.03). Among women carrying male fetuses, the RR of GDM was 1.86 (95% CI: 1.14, 2.93) for the top tertile of Cd levels compared with the bottom tertile.
conclusionsTo our knowledge, this is the first report of an association between urinary Cd levels in early pregnancy and GDM. Our findings suggest that Cd body burden increases the risk of GDM and that the association may be modified by fetal sex. https://doi.org/10.1289/EHP2716.
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