Evidence map›Paper›PMID 29424777›Full record

ArticleAIDS (London, England)2018

Impact of insurance coverage on HIV transmission potential among antiretroviral therapy-treated youth living with HIV.

Sarah Wood, Sarah Ratcliffe, Charitha Gowda, Susan Lee, Nadia L Dowshen, Robert Gross

Abstract read
In one paragraph

Article in AIDS (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah WoodCraig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia.
Sarah RatcliffeCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania.
Charitha GowdaDepartment of Pediatrics, The Ohio State University College of Medicine, Ohio.
Susan LeeCraig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia.
Nadia L DowshenCraig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia.
Robert GrossCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania.
University of Pennsylvania · USChildren's Hospital of Philadelphia · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Penn Mental Health AIDS Research CenterP30MH097488 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Knashawn Hodge Morales · 2013 to 2026
$23.5M
mHealth intervention for ART adherence and sexual risk reduction among HIV+ YMSMK23MH102128 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI DOWSHEN, NADIA L · 2014 to 2018
$875k
Social Support as a Facilitator of Adherence to HIV Pre-Exposure Prophylaxis Among Young MSM of ColorF32MH111341 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI WOOD, SARAH MARIAN · 2016 to 2018
$145k
NIAID NIH HHS L40 AI120040NIAID NIH HHS P30 AI045008NIMH NIH HHS F32 MH111341NIMH NIH HHS K23 MH102128NIMH NIH HHS P30 MH097488
6 · The paper itself

Abstract

objectiveTo identify the prevalence of high HIV transmission potential in a cohort of youth living with HIV (YLWH), and determine the impact of insurance coverage on potential for HIV transmission.

designRetrospective cohort study of antiretroviral therapy (ART)-treated YLWH at a US adolescent HIV clinic, 2002-2015.

methodsThe primary exposure was presence or absence of insurance, defined as private, public or pharmacy-only coverage. The primary outcome was high HIV transmission potential, defined as time-concurrent incident bacterial sexually transmitted infections (STI) (gonorrhea, chlamydia or syphilis) and HIV RNA greater than 1500 copies/ml. Marginal structural models adjusting for baseline demographic covariates, prior history of STI and time-varying retention in care assessed the relationship between insurance status and HIV transmission potential.

resultsParticipants (n = 240) were followed for a median of 22 (IQR 8.1-49) months after ART initiation, and were predominately African-American men and transgender women who have sex with men, with a median age at HIV diagnosis of 19 years (IQR 17-21). We identified 37 (15%) participants with at least one episode of high HIV transmission potential. Insurance coverage was associated with a greater than 50% lower odds of high HIV transmission potential (aOR 0.46, 95% CI 0.26-0.84), and history of STI at or before entry to HIV care conferred more than three-fold higher odds of high transmission potential (aOR 3.21, 95% CI 1.55-6.63).

conclusionWe found 15% of YLWH to have episodic high HIV transmission potential despite receiving ART. Insurance coverage, including pharmacy-only benefits, was protective against transmission risk, suggesting a pivotal role for universal ART coverage in treatment as prevention.

Indexed as

Disease Transmission, InfectiousAdolescentAdultAnti-Retroviral AgentsChildFemaleHIVHIV InfectionsHumansInsurance CoverageInsurance, HealthMaleRetrospective StudiesRNA, ViralSexually Transmitted Diseases, BacterialViral LoadAnti-Retroviral AgentsRNA, Viral

Identifiers

PMID29424777
PMCPMC5869094
OpenAlexW2791621307

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.