Trial reportClinical rehabilitation2018
Home-based pre-surgical psychological intervention for knee osteoarthritis (HAPPiKNEES): a feasibility randomized controlled trial.
Trial report in Clinical rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre-op CBT to Reduce the Risk for Development of Chronic Post-surgical Pain in Patients Undergoing Total Knee Arthroplasty
Effectiveness of a Prehabilitation Program on Clinical, Functional and Psychological Variables in Candidates for Hip or Knee Arthroplasty Surgery.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prehabilitation is effective in relieving pain after knee arthroplasty, but has little effect on length of stay and knee function: a meta-analysis of randomized controlled trials.Frontiers in medicine · 2025Pooled it
- Content and delivery of pre-operative interventions for patients undergoing total knee replacement: a rapid review.Systematic reviews · 2022Pooled it
- The influence of perioperative interventions targeting psychological distress on clinical outcome after total knee arthroplasty.Rheumatology international · 2020Pooled it
- Pooled it
- Outcome measures in prehabilitation interventions for total hip and knee arthroplasty: A scoping review.Clinical rehabilitation · 2026Article
- Upskilling pain relief after surgery: a scoping review of perioperative behavioral intervention efficacy and practical considerations for implementation.Regional anesthesia and pain medicine · 2025Article
- A one-day acceptance and commitment therapy workshop for the prevention of chronic post-surgical pain and long-term opioid use following spine surgery: Protocol for a pilot feasibility randomized controlled trial.Contemporary clinical trials · 2025Article
- Feasibility and acceptability of a single-session perioperative acceptance and commitment therapy workshop for preventing chronic postsurgical pain: a single-arm, non-randomized pilot trial.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Same patient but different worlds: A state-of-the-art review translating best practice psychosocial care from musculoskeletal care to the orthopaedic context.BMC musculoskeletal disorders · 2024Review
- Literature Review to Understand the Burden and Current Non-surgical Management of Moderate-Severe Pain Associated with Knee Osteoarthritis.Rheumatology and therapy · 2024Review
- Article
- Clinical value of ankle flexion and extension exercises combined with a psychological intervention in knee osteoarthritis.World journal of psychiatry · 2023Article
- Current evidence does not support the routine use of cognitive behavioural therapy in total knee arthroplasty: A systematic review.Journal of clinical orthopaedics and trauma · 2023Review
- Telemedicine-Based Digital Cognitive Behavioral Intervention for Perioperative Anxiety and Depression for Total Knee Arthroplasty.Journal of pain & relief · 2023Article
- Does resilience predict hospital length of stay after total knee arthroplasty? A prospective observational cohort study.Arthroplasty (London, England) · 2022Article
- The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.Osteoarthritis and cartilage · 2021Observational
- Article
- Differences in 1‑year outcome after primary total hip and knee arthroplasty : A cohort study in older patients with osteoarthritis.Der Orthopade · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveTo determine the feasibility of conducting a trial of a pre-surgical psychological intervention on pain, function, and mood in people with knee osteoarthritis listed for total knee arthroplasty.
designMulti-centre, mixed-methods feasibility randomized controlled trial of intervention plus usual care versus usual care.
settingParticipants' homes or hospital.
participantsPatients with knee osteoarthritis listed for total knee arthroplasty and score >7 on either subscales of Hospital Anxiety and Depression Scale.
interventionUp-to 10 sessions of psychological intervention (based on cognitive behavioural therapy). MAIN MEASURES: Feasibility outcomes (recruitment and retention rates, acceptability of trial procedures and intervention, completion of outcome measures), and standardized questionnaires assessing pain, function, and mood at baseline, and four and six months post-randomisation.
resultsOf 222 people screened, 81 did not meet inclusion criteria, 64 did not wish to participate, 26 were excluded for other reasons, and 51 were randomized. A total of 30 completed 4-month outcomes and 25 completed 6-month outcomes. Modal number of intervention sessions completed was three (range 2-8). At 6-month follow-up, mood, pain, and physical function scores were consistent with clinically important benefits from intervention, with effect sizes ranging from small ( d = 0.005) to moderate ( d = 0.74), and significant differences in physical function between intervention and usual care groups ( d = 1.16). Feedback interviews suggested that participants understood the rationale for the study, found the information provided adequate, the measures comprehensive, and the intervention acceptable.
conclusionA definitive trial is feasible, with a total sample size of 444 people. Pain is a suitable primary outcome, but best assessed 6 and 12 months post-surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.