ArticleJournal of neuropsychology2019
Neuropsychological differentiation of progressive aphasic disorders.
Article in Journal of neuropsychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06181500 (Home-Based Exercise in Primary Progressive Aphasia), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-Based Exercise in Primary Progressive Aphasia: A Pilot Study
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review.Frontiers in neurology · 2022Pooled it
- Empathy in primary progressive aphasia: Neural signatures and longitudinal trajectories.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Writing Abilities in Primary Progressive Aphasia: A Scoping Literature Review.Brain sciences · 2026Review
- Evaluating the correspondence of neuropsychological profiles with clinical diagnostic criteria for frontotemporal lobar degeneration and Alzheimer's disease: insights fromFrontiers in dementia · 2026Article
- Theory of mind deficits in non-fluent primary progressive aphasia.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Investigating changes in connected speech in nonfluent/agrammatic primary progressive aphasia following script training.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Effects of Cognitive Demand and Imaginability on Semantic Cognition in Patients with Primary Progressive Aphasia.Current Alzheimer research · 2025Article
- Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Heterogeneity and overlap in the continuum of linguistic profile of logopenic and semantic variants of primary progressive aphasia: a Profile Analysis based on Multidimensional Scaling study.Alzheimer's research & therapy · 2024Article
- Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- The characteristics and reproducibility of motor speech functional neuroimaging in healthy controls.Frontiers in human neuroscience · 2024Article
- The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.Alzheimer's research & therapy · 2023Article
- Anomia: Deciphering Functional Neuroanatomy in Primary Progressive Aphasia Variants.Brain sciences · 2023Article
- Frontotemporal Dementia, Where Do We Stand? A Narrative Review.International journal of molecular sciences · 2023Review
- Review
- Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer's Disease.Brain sciences · 2023Article
- Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia.Brain : a journal of neurology · 2022Review
- A syntax-lexicon trade-off in language production.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neuropsychological Profiles of Patients with Progressive Apraxia of Speech and Aphasia.Journal of the International Neuropsychological Society : JINS · 2022Article
- Neuroanatomical correlations of visuospatial processing in primary progressive aphasia.Brain communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differentiation of subtypes of primary progressive aphasia (PPA) remains challenging. We aimed to identify optimum neuropsychological measures for characterizing PPA, to examine the relationship between behavioural change and subtypes of PPA and to determine whether characteristic profiles of language, working memory, and behavioural changes occur in PPA. Forty-seven patients with PPA and multi-domain Alzheimer's disease (AD) together with 19 age-matched controls underwent a large battery of working memory and language tests. We found that simple tasks of sentence ordering, narrative production, and buccofacial praxis were particularly useful in differentiating non-fluent/agrammatic variant PPA (nfvPPA) from other PPA subtypes, whereas a test of single word comprehension was useful in detecting semantic dementia (SD). No individual tests were discriminating for logopenic variant PPA (lvPPA) relative to nfvPPA. LvPPA and multidomain AD exhibited similar language profiles. A principal components analysis revealed that characteristic PPA profiles extended beyond the realms of language, in particular, the presence of apraxia in nfvPPA, behavioural changes in SD, and working memory deficits in lvPPA. These findings suggest that not all tests are equally discriminatory for PPA and highlight the importance of a test profile in differentiating PPA. These results also support the view that lvPPA is a focal form of AD and emphasize the difficulties classifying lvPPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.