ReviewOrthopaedic surgery2018
Perioperative Blood Management Strategies for Total Knee Arthroplasty.
Review in Orthopaedic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05691751 (Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA), which is not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood Loss Assessment in the Limited Application of Tourniquet During Primary Unilateral TKA: a Randomized Controlled Study
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Comparison of postoperative blood loss in cementless and cemented total knee arthroplasty: a systematic review.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Indicators and medical tests to identify lower limb swelling causes after total knee arthroplasty: a Delphi study with multidisciplinary experts.Journal of orthopaedic surgery and research · 2023Pooled it
- Comparison of clinical outcomes of VISIONAIRE patient-specific instrumentation with conventional instrumentation in total knee arthroplasty: a systematic literature review and meta-analysis.Archives of orthopaedic and trauma surgery · 2023Pooled it
- The impact of surgical trainee involvement in total knee arthroplasty: a systematic review of surgical efficacy, patient safety, and outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Pooled it
- Tranexamic acid is beneficial for blood management of high tibial osteotomy: a randomized controlled study.Archives of orthopaedic and trauma surgery · 2021Trial
- Topical co-delivery of platelet rich fibrin and tranexamic acid does not decrease blood loss in primary total knee arthroplasty compared to the standard of care: a prospective, randomized, controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Trial
- Association of oxidized regenerated cellulose powder and tranexamic acid during total knee arthroplasty: clinical outcomes.International orthopaedics · 2026Article
- Interpretable Machine Learning Analysis of Factors Associated with Postoperative Hemoglobin Reduction After Total Knee Arthroplasty: A Standardized-Protocol Cohort Study in Non-Transfused Patients.Journal of clinical medicine · 2026Article
- Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Blood transfusion in total knee arthroplasty and total hip arthroplasty: A nationwide study of complications, costs and predictive modelling.Journal of experimental orthopaedics · 2025Article
- Intra-Articular Injection of Bupivacaine and Adrenaline Reduces Intraoperative and Postoperative Blood Loss in Total Knee Arthroplasty: A Retrospective Case-Control Study.Clinics and practice · 2025Article
- Trends, risk factors, and complications of blood transfusion in primary total knee arthroplasty in China: a nationwide retrospective study.Archives of orthopaedic and trauma surgery · 2025Article
- Article
- Should We Regularly Assess Hemoglobin Levels Following Elective Total Knee Arthroplasty, with the Administration of TXA and Without the Usage Tourniquet? An Observational Study from a Single Center.Medicina (Kaunas, Lithuania) · 2024Observational
- Article
- Comparative analysis of acute blood loss anemia in robotic assisted vs. manual instrumented total knee arthroplasty.Journal of orthopaedics · 2024Article
- Early ambulation after total knee arthroplasty: a retrospective single-center study.Journal of orthopaedic surgery and research · 2024Article
- Impact of intra- and extramedullary alignment on blood loss in total knee arthroplasty: a retrospective study.Archives of orthopaedic and trauma surgery · 2024Article
- Evaluating the Efficacy and Safety of Combined Administration of Systemic and Topical Tranexamic Acid in Total Knee Arthroplasty.Journal of orthopaedic case reports · 2024Article
- Associations of preoperative anemia and postoperative hemoglobin values with hospital costs in total knee arthroplasty (TKA).Archives of orthopaedic and trauma surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total knee arthroplasty (TKA) often causes a significant amount of blood loss with an accompanying decline in hemoglobin and may increase the frequency of allogeneic blood transfusion rates. Unfortunately, allogeneic blood transfusions have associated risks including postoperative confusion, infection, cardiac arrhythmia, fluid overload, increased length of hospital stay, and increased mortality. Other than reducing the need for blood transfusions, reducing perioperative blood loss in TKA may also minimize intra-articular hemorrhage, limb swelling, and postoperative pain, and increase the range of motion during the early postoperative period. These benefits improve rehabilitation success and increase patients' postoperative satisfaction. Preoperative anemia, coupled with intraoperative and postoperative blood loss, is a major factor associated with higher rates of blood transfusion in TKA. Thus, treatment of preoperative anemia and prevention of perioperative blood loss are the primary strategies for perioperative blood management in TKA. This review, combined with current evidence, analyzes various methods of blood conservation, including preoperative, intraoperative, and postoperative methods, in terms of their effectiveness, safety, and cost. Because many factors can be controlled to reduce blood loss and transfusion rates in TKA, a highly efficient, safe, and cost-effective blood management strategy can be constructed to eliminate the need for transfusions associated with TKA.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.