ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
Relationships between electrical and mechanical dyssynchrony in patients with left bundle branch block and healthy controls.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of Left and Right Bundle Branch Block on Left Ventricular Systolic Function and Myocardial Mechanics Assessed by Speckle-Tracking Echocardiography and Cardiac Magnetic Resonance Feature Tracking: A Systematic Review and Meta-Analysis.Echocardiography (Mount Kisco, N.Y.) · 2026Pooled it
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Local electromechanical alterations determine the left ventricle rotational dynamics in CRT-eligible heart failure patients.Scientific reports · 2021Trial
- Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- R-wave amplitude changes in lead aVL predict outcomes in cardiac resynchronization therapy: Exploring the role of papillary muscle dyssynchrony and mitral regurgitation.Heart rhythm O2 · 2025Article
- A Prospective Pilot Study for Prognosis of Cardiac Resynchronization Therapy Super-Response Using Electrical and Mechanical Dyssynchrony Assessment in Patients with Heart Failure and Strauss Left Bundle Branch Block Criteria.Life (Basel, Switzerland) · 2025Article
- The Functional and Imaging Implications of Left Bundle Branch Pacing in Ischemic Cardiomyopathy.Biomolecules · 2025Review
- Outcomes with T-wave discordance of left bundle branch block and preserved or mildly reduced ejection fraction.ESC heart failure · 2024Article
- Mechanical Dyssynchrony of Isolated Left and Right Ventricular Human Myocardium in End-Stage Heart Failure.Circulation. Heart failure · 2023Article
- Dyssynchronous Left Ventricular Activation is Insufficient for the Breakdown of Wringing Rotation.Frontiers in physiology · 2022Article
- Regional contributions to left ventricular stroke volume determined by cardiac magnetic resonance imaging in cardiac resynchronization therapy.BMC cardiovascular disorders · 2021Article
- Mechanisms of left ventricular dyssynchrony: A multinational SPECT study of patients with bundle branch block.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prognostic value of integrative analysis of electrical and mechanical dyssynchrony in patients with acute heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Perspective and future direction of intraventricular mechanical dyssynchrony assessment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Intraventricular synchronism assessment by gated-SPECT myocardial perfusion imaging in cardiac resynchronization therapy. Does cardiomyopathy type influence results?EJNMMI research · 2020Article
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Electrical and mechanical dyssynchrony in patients with right bundle branch block.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- True complete left bundle branch block reveals dyssynchrony evaluated by semiconductor single-photon emission computed tomography.Journal of arrhythmia · 2019Article
- Analysis of Cardiac Dyssynchrony - An Unsolved Issue! How to improve selection and response to Cardiac Resynchronization Therapy?Arquivos brasileiros de cardiologia · 2018Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal electrical activation may cause dyssynchronous left ventricular (LV) contraction. In this study, we characterized and analyzed electrical and mechanical dyssynchrony in patient with left bundle branch block (LBBB) and healthy controls.
methodsMyocardial perfusion imaging (MPI) data from 994 patients were analyzed. Forty-three patient fulfilled criteria for LBBB and 24 for controls. Electrical activation was characterized with vector electrocardiography (VECG) and LV function including mechanical dyssynchrony with ECG-gated MPI phase analysis.
resultsQRS duration (QRSd; r = 0.69, P < .001) and a few other VECG parameters correlated significantly with phase bandwidth (phaseBW) representing mechanical dyssynchrony. End-diastolic volume (EDV; r = 0.59, P < .001), ejection fraction and end-systolic volume correlated also with phaseBW. QRSd (β = 0.47, P < .001) and EDV (β = 0.36, P = .001) were independently associated with phaseBW explaining 55% of its variation. Sixty percent of patients with LBBB had significant mechanical dyssynchrony. Those patients had wider QRSd (159 vs 147 ms, P = .013) and larger EDV (144 vs 94 mL, P = .008) than those with synchronous LV contraction. Cut-off values for mechanical dyssynchrony seen in patients with LBBB were QRSd ≥ 165 ms and EDV ≥ 109 mL.
conclusionsDespite obvious conduction abnormality, LBBB is not always accompanied by mechanical dyssynchrony. QRSd and EDV explained 55% of variation seen in phaseBW. These two parameters were statistically different between LBBB cases with and without mechanical dyssynchrony.
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