Evidence map›Paper›PMID 29423819›Full record

ArticleMolecular neurobiology2018

Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases.

Jalaluddin M Ashraf, Mohammad Azam Ansari, Sana Fatma, Saleh M S Abdullah, Johar Iqbal, Aymen Madkhali, Al Hassan Hamali, Saheem Ahmad, Ahmed Jerah, Valentina Echeverria and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Vanillic Acid Inhibited the Induced Glycation Using In Vitro and In Vivo Models.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  12. Current Strategies and Potential Prospects for Nanoparticle-Mediated Treatment of Diabetic Nephropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Review
  13. Article
  14. Review
  15. Biosynthesized ZnO-NPs fromBiomolecules · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 4 countries.

Jalaluddin M AshrafFaculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia. jmashraf@gmail.com.
Mohammad Azam AnsariDepartment of Epidemic Disease Research, Institute of Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, 31441, Saudi Arabia. azammicro@gmail.com.
Sana FatmaInstitute of Science, Banaras Hindu University, Varanasi, India.
Saleh M S AbdullahFaculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Johar IqbalFaculty of Medicine, Jazan University, Jazan, Saudi Arabia.
Aymen MadkhaliFaculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Al Hassan HamaliFaculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Saheem AhmadDepartment of Biosciences, Integral University, Lucknow, India.
Ahmed JerahFaculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Valentina EcheverriaFacultad de Ciencias de la Salud, Universidad San Sebastián, Lientur 1457, 4030000, Concepción, Chile.
George E BarretoDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.ORCID http://orcid.org/0000-0002-6644-1971
Ghulam Md AshrafKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. ashraf.gm@gmail.com.
Jazan University · SABanaras Hindu University · INImam Abdulrahman Bin Faisal University · SAIntegral University · INKing Abdulaziz University · SAPontificia Universidad Javeriana · COSan Sebastián University · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson's diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications.

Indexed as

AloeGlycation End Products, AdvancedHumansNanoparticlesNeurodegenerative DiseasesOxidation-ReductionOxidative StressPlant ExtractsPlant LeavesSpectrometry, FluorescenceSpectrophotometry, UltravioletX-Ray DiffractionZinc OxideGlycation End Products, AdvancedPlant ExtractsZinc OxideAdvanced glycation end productsAnti-glycating agentNanoparticlesNeurodegenerative diseases

Identifiers

PMID29423819
OpenAlexW2788092478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.