Evidence map›Paper›PMID 29423775›Full record

ArticleLifetime data analysis2019

A class of semiparametric cure models with current status data.

Guoqing Diao, Ao Yuan

Abstract read
In one paragraph

Article in Lifetime data analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Guoqing DiaoDepartment of Statistics, George Mason University, Fairfax, VA, USA. gdiao@gmu.edu.ORCID 0000-0001-7304-9591
Ao YuanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University, Washington, DC, USA.

Funding

STATISTICAL METHODOLOGY FOR CANCER CLINICAL TRIALSR01CA087746 · NCI · UNIVERSITY OF MARYLAND BALT CO CAMPUS · PI ROSENBERGER, WILLIAM F. · 2000 to 2004
$631k
Statistical Methods in Cancer ResearchR15CA150698 · NCI · GEORGE MASON UNIVERSITY · PI ROSENBERGER, WILLIAM F. · 2010 to 2010
$409k
NCI NIH HHS R01 CA087746NCI NIH HHS R15 CA150698NCI NIH HHS R15CA150698-01
6 · The paper itself

Abstract

Current status data occur in many biomedical studies where we only know whether the event of interest occurs before or after a particular time point. In practice, some subjects may never experience the event of interest, i.e., a certain fraction of the population is cured or is not susceptible to the event of interest. We consider a class of semiparametric transformation cure models for current status data with a survival fraction. This class includes both the proportional hazards and the proportional odds cure models as two special cases. We develop efficient likelihood-based estimation and inference procedures. We show that the maximum likelihood estimators for the regression coefficients are consistent, asymptotically normal, and asymptotically efficient. Simulation studies demonstrate that the proposed methods perform well in finite samples. For illustration, we provide an application of the models to a study on the calcification of the hydrogel intraocular lenses.

Indexed as

Computer SimulationModels, StatisticalProportional Hazards ModelsAlgorithmsBiometryData AnalysisFemaleHumansLikelihood FunctionsMaleSensitivity and SpecificityBox–Cox transformationCure fractionEmpirical processNPMLEProportional hazards cure modelProportional odds cure modelSemiparametric efficiency

Identifiers

PMID29423775
PMCPMC6082745

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.