ArticleAnnals of biomedical engineering2018
Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate.
Article in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Acute and chronic injury of the knee articular cartilage: prevalence, injury mechanisms, MRI assessment and association with osteoarthritis.Skeletal radiology · 2026Review
- Photobiomodulation outperforms ultrasound in reducing IL-1APL bioengineering · 2026Article
- MMP release following cartilage injury leads to collagen loss in intact tissue: A computational study.PLoS computational biology · 2026Article
- Peak, cumulative and rate of medial and lateral compartment joint loading during gait following total knee arthroplasty.Gait & posture · 2025Article
- Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation.Journal of biomechanical engineering · 2022Article
- Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis-Finite element modeling and MRI follow-up of ACL reconstructed patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Efficacy of rectus femoris stretching on pain, range of motion and spatiotemporal gait parameters in patients with knee osteoarthritis: a randomised controlled trial.BMJ open sport & exercise medicine · 2022Article
- Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage.Acta biomaterialia · 2021Article
- The Relationship Between Proteoglycan Loss, Overloading-Induced Collagen Damage, and Cyclic Loading in Articular Cartilage.Cartilage · 2021Article
- Articular Cartilage Friction, Strain, and Viability Under Physiological to Pathological Benchtop Sliding Conditions.Cellular and molecular bioengineering · 2021Article
- Triborheological Study under Physiological Conditions of PVA Hydrogel/HA Lubricant as Synthetic System for Soft Tissue Replacement.Polymers · 2021Article
- Anisotropic properties of articular cartilage in an accelerated in vitro wear test.Journal of the mechanical behavior of biomedical materials · 2020Article
- Review
- Microplate assay for denatured collagen using collagen hybridizing peptides.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Cartilage defect location and stiffness predispose the tibiofemoral joint to aberrant loading conditions during stance phase of gait.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Collagen damage in articular cartilage is considered nearly irreversible and may be an early indication of cartilage degeneration. Surface fibrillation and internal collagen damage may both develop after overloading. This study hypothesizes that damage develops at these different locations, because the distribution of excessive strains varies with loading rate as a consequence of time-dependent cartilage properties. The objective is to explore whether collagen damage could preferentially occur superficially or internally, depending on the magnitude and rate of overloading. Bovine osteochondral plugs were compressed with a 2 mm diameter indenter to 15, 25, 35 and 45 N, and at 5, 60 and 120 mm/min. Surface fibrillation and internal collagen damage were graded by four observers, based on histology and staining of collagen damage. Results show that loading magnitude affects the degree of collagen damage, while loading rate dominates the location of network damage: low rates predominantly damage superficial collagen, while at high rates, internal collagen damage occurs. The proposed explanation for the rate-dependent location is that internal fluid flows govern the time-dependent internal tissue deformation and therewith the location of overstained and damaged areas. This supports the hypothesis that collagen damage development is influenced by the time-dependent material behaviour of cartilage.
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