Rapid Reversal of Complete Binocular Blindness With High-Dose Corticosteroids and Lumbar Drain in a Solid Organ Transplant Recipient With Cryptococcal Meningitis and Immune Reconstitution Syndrome: First Case Study and Literature Review.

Zoe Weiss, Nihaal Mehta, Su Nandar Aung, Michael Migliori, Dimitrios Farmakiotis

Abstract read

In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Corticosteroids for Posttransplant Immune Reconstitution Syndrome inOpen forum infectious diseases · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zoe WeissDepartment of Internal Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Nihaal MehtaWarren AlpertMedical School of Brown University, Providence, Rhode Island.

Su Nandar AungDivision of Infectious Disease, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Michael MiglioriDivision of Ophthalmology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Dimitrios FarmakiotisDivision of Infectious Disease, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Isl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blindness is a rare, devastating, usually permanent complication of cryptococcal meningitis (CM). We present the first case of complete vision loss in a solid organ transplant recipient with CM treated with placement of a lumbar drain who had a dramatic visual recovery that started after 3 doses of high-dose steroids.

Indexed as

CM-IRIScryptococcal meningitisimmune reconstitution inflammatory syndromevision loss

Identifiers

PMID29423423

DOI10.1093/ofid/ofy007

PMCPMC5798033

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.