ArticleCell discovery2018
Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates.
Open access · goldAbstract read
In one paragraph
Article in Cell discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Clonal hematopoiesis of indeterminate potential (CHIP)-a pivotal contributor of aging and related disorders.Annals of translational medicine · 2026Review
- HES1 regulates bone marrow mesenchymal stromal cell function by suppressing NFATc2-mediated inflammation.Haematologica · 2026Article
- ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigenetic Reprogramming of the Asxl1/LXRα-H3K4me3 Axis.Journal of neuroinflammation · 2026Article
- Chronic Myelomonocytic Leukemia Microenvironment in Disease Progression and Therapy: Focus on Stepwise Reconfiguring of Myeloid-Immune Cell Interactions Driving Immune Tolerance.Current hematologic malignancy reports · 2025Review
- Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.Stem cell reports · 2025Article
- The rewired immune microenvironment in leukemia.Nature immunology · 2025Review
- Amplification-free sensitive detection of Staphylococcus aureus by spherical nucleic acid triggered CRISPR/Cas12a and Poly T-Cu reporter.Mikrochimica acta · 2025Article
- Generation and Characterization of Induced Pluripotent Stem Cells Carrying An ASXL1 Mutation.Stem cell reviews and reports · 2024Article
- Additional Sex Combs-like Family Associated with Epigenetic Regulation.International journal of molecular sciences · 2024Review
- The Role of Inflammation in the Initiation and Progression of Myeloid Neoplasms.Blood cancer discovery · 2023Article
- Epigenetic regulation by ASXL1 in myeloid malignancies.International journal of hematology · 2023Review
- The long and winding road: homeostatic and disordered haematopoietic microenvironmental niches: a narrative review.Biomaterials translational · 2022Review
- Tumorigenic Aspects of MSC Senescence-Implication in Cancer Development and Therapy.Journal of personalized medicine · 2021Review
- Hematopoiesis during Ontogenesis, Adult Life, and Aging.International journal of molecular sciences · 2021Review
- Development of a poor-prognostic-mutations derived immune prognostic model for acute myeloid leukemia.Scientific reports · 2021Article
- Review
- Deregulation of tumor suppressive ASXL1-PTEN/AKT axis in myeloid malignancies.Journal of molecular cell biology · 2020Article
- Hcfc1a regulates neural precursor proliferation and asxl1 expression in the developing brain.BMC neuroscience · 2020Article
- Impact of mesenchymal stem cell senescence on inflammaging.BMB reports · 2020Review
- The role of ASXL1 in hematopoiesis and myeloid malignancies.Cellular and molecular life sciences : CMLS · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 2 countries.
Peng Zhang *1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Zizhen Chen *3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Rong Li *3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Ying Guo1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Hui Shi3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Jie Bai3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Hui Yang1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Mengyao Sheng3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Zhaomin Li1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Zhuo Li1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Jianping Li1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Shi Chen1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Weiping Yuan3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.ORCID 0000-0001-8288-5022
Tao Cheng3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Mingjiang Xu1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
Yuan Zhou3State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital and Center for Stem Cell Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020 China.
Feng-Chun Yang1Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
University of Miami · USChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
Role of Asxl1 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01CA172408 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2024
$3.4MRole of TET2 in normal hematopoiesis and pathogenesis of myeloid malignanciesR01HL112294 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG · 2012 to 2016
$1.9MNo-nonsense approach to treat myeloid malignancies with ASXL1 nonsense mutationsR21CA185751 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI XU, MINGJIANG, YANG, FENG-CHUN · 2014 to 2015
$370kNCI NIH HHS R01 CA172408NCI NIH HHS R21 CA185751NHLBI NIH HHS R01 HL112294
Abstract
Somatic or de novo mutations of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.