ArticleClinical kidney journal2018
Renal recovery after severe acute kidney injury in critically ill myeloma patients: a retrospective study.
Article in Clinical kidney journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Assessing renal recovery after acute kidney injury in elderly patients: a retrospective cohort study.Renal failure · 2025Article
- Critically ill cancer patient's resuscitation: a Belgian/French societies' consensus conference.Intensive care medicine · 2021Article
- Article
- Hemodiafiltration with ultrafiltrate regeneration reduces free light chains without albumin loss in multiple myeloma patients.BMC nephrology · 2020Observational
- Multiple Myeloma Mimicking a Small Vessel Vasculitis Presentation.Case reports in rheumatology · 2020Article
- The newClinical kidney journal · 2019Article
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Authors and funding
10 authors.
Funding
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Abstract
backgroundDespite substantial improvements in the management of multiple myeloma, renal failure remains an important burden that tremendously impairs prognosis. The purpose of this study was to describe the characteristics and to establish prognostic factors of renal recovery in myeloma patients admitted to the intensive care unit (ICU) for acute kidney injury (AKI) Stage 3 treated with renal replacement therapy (RRT).
methodsA retrospective single-centre cohort study was performed, including consecutive myeloma patients admitted to one medical ICU between 1 January 2007 and 1 September 2015 and treated with RRT. Patients were evaluated 60 days after initiation of RRT and divided into three groups: alive without dialysis, alive and dialysis-dependent or deceased. A univariate analysis was performed to identify factors associated with renal recovery (alive without dialysis 60 days after initiation of RRT).
resultsFifty patients were included in the study. Mean age was 63 (interquartile range: 58-70) years and 32 (64%) were male. Patients were admitted to the ICU 4 (1-7) years after the diagnosis of myeloma. Twenty-one (42%) had already been treated with high-dose therapy combined with autologous stem cell transplantation. Baseline renal function evaluated by estimated glomerular filtration rate (GFR) before ICU admission was 63 (44-90) mL/min/1.73 m
conclusionsAKI Stage 3 in critically ill myeloma patients was associated with a lower than expected hospital mortality. Patients with a high level of proteinuria and a history of high-dose therapy combined with autologous stem cell transplantation were less likely to recover their renal function at Day 60. KEY WORDS: dialysis, intensive care, multiple myeloma, prognosis, proteinuria.
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