Evidence map›Paper›PMID 29423024›Full record

ArticleOncotarget2018

A novel multiplex detection array revealed systemic complement activation in oral squamous cell carcinoma.

Juliane Gallenkamp, Gerrit Spanier, Elisabeth Wörle, Markus Englbrecht, Michael Kirschfink, Roman Greslechner, Regine Braun, Nicole Schäfer, Richard J Bauer, Diana Pauly

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Prediction of Oral Cancer Biomarkers by Salivary Proteomics Data.International journal of molecular sciences · 2024
    Article
  3. Article
  4. Targeting the Complement Pathway in Malignant Glioma Microenvironments.Frontiers in cell and developmental biology · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Complement System in Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2019
    Review
  11. Role of C5b-9 and RGC-32 in Cancer.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Juliane GallenkampUniversity Hospital Regensburg, Department of Oral and Maxillofacial Surgery, Regensburg, Germany.
Gerrit SpanierUniversity Hospital Regensburg, Department of Oral and Maxillofacial Surgery, Regensburg, Germany.
Elisabeth WörleUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Markus EnglbrechtUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Michael KirschfinkInstitute of Immunology, University of Heidelberg, Heidelberg, Germany.
Roman GreslechnerUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Regine BraunUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Nicole SchäferUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
Richard J BauerUniversity Hospital Regensburg, Department of Oral and Maxillofacial Surgery, Regensburg, Germany.
Diana PaulyUniversity Hospital Regensburg, Department of Ophthalmology, Regensburg, Germany.
University Hospital Regensburg · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common tumors within the oral cavity. Early diagnosis and prognosis tools are urgently needed. This study aimed to investigate the activation of the complement system in OSCC patients as potential biomarker. Therefore, an innovative complement activation array was developed. Characterized antibodies detecting the complement activation specific epitopes C3a, C5a and sC5b-9 along with control antibodies were implemented into a suspension bead array. Human serum from a healthy (

Indexed as

C3aC5acomplement proteinsmulitplex assayoral squamous cell carcinoma

Identifiers

PMID29423024
PMCPMC5790441
OpenAlexW2771223448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.