ArticleAmerican journal of translational research2018
Generation of an acute retinal photoreceptor degeneration model in rabbits.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Seasonal Variation in ATP-Induced Retinal Damage in the Cone-Dominant 13-Lined Ground Squirrel.Translational vision science & technology · 2024Article
- Chemically induced cone degeneration in the 13-lined ground squirrel.Visual neuroscience · 2024Article
- Modeling of Retinal Degeneration.Bulletin of experimental biology and medicine · 2021Article
- Ultrasound Biomicroscopy Diagnosis Analysis and Fine Care of Anterior Segment Injury of Traumatic Anterior Chamber Based on Intelligent Virtual Reality Technology.Journal of healthcare engineering · 2021Article
- Article
- Spectral Domain Optical Coherence Tomography in Awake Rabbits Allows Identification of the Visual Streak, a Comparison with Histology.Translational vision science & technology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the appropriate dose of sodium nitroprusside for establishing acute retinal photoreceptor degeneration models in rabbits.
methodsSodium nitroprusside (SNP) was delivered intravitreously. Sixteen New Zealand White rabbits are divided into four groups randomly: 0.1 mM, 0.25 mM, 0.5 mM SNP intravitreal injection group (experimental groups), and normal saline intravitreal injection group (control group). Assessments included weight, anterior segment photography, fundus photography, Hematoxylin-eosin staining, immunofluorescence, multi-focal electroretinogram (mfERG) and pupillary direct light reflex were performed at baseline and day 28 after injection. The spectral domain optical coherence tomography (SD-OCT) and full field electroretinogram (fERG) were performed at baseline and day 1, 3, 7, 14, 21 and 28 after injection.
resultsNo complications and no significant different in weight were found among all groups. No obvious change was found by slit lamp and fundus photography after injection in all groups. In SD-OCT exams, a time-dependent and dose-dependent injury of photoreceptor was found in SNP injection groups (
conclusionsSodium nitroprusside of 0.1 mM and 0.25 mM can lead to monolayer photoreceptor degeneration at posterior pole in rabbits and the lesion is stable at 1 month after SNP injection.
Indexed as
Identifiers
29423008PMC5801361W2955012744What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.