ArticleBiotechnology for biofuels2018
Combinatorial pretreatment and fermentation optimization enabled a record yield on lignin bioconversion.
Article in Biotechnology for biofuels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 106 citations in OpenAlex.
- Synthetic bacterial consortium for degradation of plastic pyrolysis oil waste: experimental optimization and neural network modeling.Frontiers in microbiology · 2026Article
- Benzenoid Aromatics from Renewable Resources.Chemical reviews · 2024Review
- Lignin bioconversion based on genome mining for ligninolytic genes in Erwinia billingiae QL-Z3.Biotechnology for biofuels and bioproducts · 2024Article
- Lignin Extraction by Using Two-Step Fractionation: A Review.Molecules (Basel, Switzerland) · 2023Review
- Recent Advancements and Challenges in Lignin Valorization: Green Routes towards Sustainable Bioproducts.Molecules (Basel, Switzerland) · 2022Review
- Microbial Valorization of Lignin to Bioplastic by Genome-ReducedFrontiers in microbiology · 2022Article
- Recent Biotechnology Advances in Bio-Conversion of Lignin to Lipids by Bacterial Cultures.Frontiers in chemistry · 2022Review
- Transforming biorefinery designs with 'Plug-In Processes of Lignin' to enable economic waste valorization.Nature communications · 2021Article
- A Review on the Utilization of Lignin as a Fermentation Substrate to Produce Lignin-Modifying Enzymes and Other Value-Added Products.Molecules (Basel, Switzerland) · 2021Review
- Depolymerization and conversion of lignin to value-added bioproducts by microbial and enzymatic catalysis.Biotechnology for biofuels · 2021Review
- Adaptive laboratory evolution ofMetabolic engineering communications · 2020Article
- Enterotype identification and its influence on regulating the duodenum metabolism in chickens.Poultry science · 2020Article
- Bioprospecting Microbial Diversity for Lignin Valorization: Dry and Wet Screening Methods.Frontiers in microbiology · 2020Review
- Promoting microbial utilization of phenolic substrates from bio-oil.Journal of industrial microbiology & biotechnology · 2019Article
- Recent advances in lignin valorization with bacterial cultures: microorganisms, metabolic pathways, and bio-products.Biotechnology for biofuels · 2019Review
- Boosting Ethanol Productivity ofFrontiers in microbiology · 2019Article
- Lipid metabolism of phenol-tolerantBiotechnology for biofuels · 2018Article
- Systems and Synthetic Biology Approaches to Engineer Fungi for Fine Chemical Production.Frontiers in bioengineering and biotechnology · 2018Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLignin valorization has recently been considered to be an essential process for sustainable and cost-effective biorefineries. Lignin represents a potential new feedstock for value-added products. Oleaginous bacteria such as
resultsAs opposed to single pretreatment, combinatorial pretreatment produced a 12.8-75.6% higher lipid concentration in fermentation using lignin as the carbon source. Gas chromatography-mass spectrometry analysis showed that combinatorial pretreatment released more aromatic monomers, which could be more readily utilized by lignin-degrading strains. Three detoxification strategies were used to remove potential inhibitors produced from pretreatment. After heating detoxification of the lignin stream, the lipid concentration further increased by 2.9-9.7%. Different fermentation strategies were evaluated in scale-up lipid fermentation using a 2.0-l fermenter. With laccase treatment of the lignin stream produced from combinatorial pretreatment, the highest cell dry weight and lipid concentration were 10.1 and 1.83 g/l, respectively, in fed-batch fermentation, with a total soluble substrate concentration of 40 g/l. The improvement of the lipid fermentation performance may have resulted from lignin depolymerization by the combinatorial pretreatment and laccase treatment, reduced inhibition effects by fed-batch fermentation, adequate oxygen supply, and an accurate pH control in the fermenter.
conclusionsOverall, these results demonstrate that combinatorial pretreatment, together with fermentation optimization, favorably improves lipid production using lignin as the carbon source. Combinatorial pretreatment integrated with fed-batch fermentation was an effective strategy to improve the bioconversion of lignin into lipids, thus facilitating lignin valorization in biorefineries.
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