ArticlePsychiatry investigation2018
Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis.
Article in Psychiatry investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical morphology in patients with the deficit and non-deficit syndrome of schizophrenia: a worldwide meta- and mega-analyses.Molecular psychiatry · 2023Pooled it
- A Systematic Review of the Magnetic Resonance Imaging Literature Investigating the Deficit Syndrome in Schizophrenia.Schizophrenia bulletin open · 2026Article
- Neural association between mental symptoms and facial emotion recognition in deficit schizophrenia: an fNIRS study.BMC psychiatry · 2025Article
- Negative Symptoms in Schizophrenia: An Update on Research Assessment and the Current and Upcoming Treatment Landscape.CNS drugs · 2025Review
- Prefrontal Oscillatory Slowing in Early-Course Schizophrenia Is Associated With Worse Cognitive Performance and Negative Symptoms: A Transcranial Magnetic Stimulation-Electroencephalography Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2024Article
- Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.Schizophrenia bulletin open · 2023Article
- Contrasting Frontoparietal Network Connectivity in Antipsychotic Medication-Naive First-Episode Psychosis Patients Who Do and Do Not Display Features of the Deficit Syndrome.Schizophrenia bulletin · 2022Article
- Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia.Journal of clinical medicine · 2022Article
- The Deficit Schizophrenia Subtype Is Associated with Low Adherence to the Mediterranean Diet: Findings from a Case-Control Study.Journal of clinical medicine · 2022Article
- Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia.Frontiers in immunology · 2022Article
- White Matter Neurometabolic Signatures Support the Deficit and Nondeficit Distinction in Antipsychotic-Naïve First-Episode Psychosis Patients.Schizophrenia bulletin · 2021Article
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3 authors.
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Abstract
The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20-25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine the current prevalence of DS, including international and most recent studies. Thirteen observational studies met the inclusion criteria, comprising 2092 patients from eight countries. Pooled proportion of the DS subgroup was 32.64%, higher than previously reported. Based on our outcomes, up to one-third of patients with schizophrenia might have idiopathic and stable negative symptoms. This significant proportion of patients should be well represented in clinical trial's samples.
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