ArticlePsychiatry investigation2018
Is the Relationship between Depression and C Reactive Protein Level Moderated by Social Support in Elderly?-Korean Social Life, Health, and Aging Project (KSHAP).
Article in Psychiatry investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Association between social supports and negative emotions among pediatric residents in China: The chain-mediating role of psychological resilience and burnout.Frontiers in public health · 2022Article
- Racial and ethnic differences in the associations between social integration, C-reactive protein and depressive symptoms.SSM - population health · 2020Article
- C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy.Psychiatry investigation · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
objectiveTo investigate the buffering effects of social support as an effects modifier in the association between depression and inflammation in the elderly.
methodsWe analyzed the Korean Social Life, Health, and Aging Project (KSHAP) for questionnaire, clinical, and laboratory data of 530 older adults living in a rural community. Multivariate regression models were used to investigate the association between depressive symptoms and C-reactive protein level (CRP), a marker of inflammation, at varying levels of social support.
resultsSocial support affected the association between depressive symptoms and CRP level in both sexes. However, the direction of effects modification was different for men and women. In men, a higher CRP level was significantly associated with depressive symptoms only among those with lower support from a spouse or family members. By contrast, in women, the association was significant only among subgroups with higher spousal or family support. Social support from neighbors or friends did not affect the depression-inflammation relationship in men but modestly affected the relationship in women.
conclusionOur findings suggest that social support may have a buffering effect in the relationship between depression and inflammation in elderly Koreans. But the influence of social support may run in different directions for men and women.
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