Evidence map›Paper›PMID 29422769›Full record

SynthesisMolecular vision2018

A genome-wide association study of corneal astigmatism: The CREAM Consortium.

Rupal L Shah, Qing Li, Wanting Zhao, Milly S Tedja, J Willem L Tideman, Anthony P Khawaja, Qiao Fan, Seyhan Yazar, Katie M Williams, Virginie J M Verhoeven and 34 more

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC
In one paragraph

Synthesis in Molecular vision, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [Astigmatism].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 20 institutions in 10 countries.

Rupal L ShahSchool of Optometry & Vision Sciences, Cardiff University, Cardiff, UK.
Qing LiComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA.
Wanting ZhaoSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Milly S TedjaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
J Willem L TidemanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Anthony P KhawajaDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Qiao FanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Seyhan YazarInstitute of Genetics and Molecular Medicine, Medical Research Council Human Genetics Unit, University of Edinburgh, Edinburgh, UK.
Katie M WilliamsDepartment of Ophthalmology, King's College London, London, UK.
Virginie J M VerhoevenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jing XieCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing, China.
Moritz HessInstitute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany.
Stefan NickelsDepartment of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
Karl J LacknerInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.
Olavi PärssinenDepartment of Ophthalmology, Central Hospital of Central Finland, Jyväskylä, Finland.
Juho WedenojaDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Maria Pina ConcasInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
André UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Vincent W V JaddoeDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Pirro G HysiDepartment of Ophthalmology, King's College London, London, UK.
Xueling SimSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Nicholas TanSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yih-Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Sonoko SensakiSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Johannes R VingerlingDepartment of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jost B JonasBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing, China.
Paul MitchellDepartment of Ophthalmology, Western Sydney Local Health District, Sydney, Australia.
Christopher J HammondDepartment of Ophthalmology, King's College London, London, UK.
René HöhnDepartment of Ophthalmology, University Medical Center Mainz, Mainz, Germany.
Paul N BairdCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Tien-Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Chinfsg-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Yik Ying TeoSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
David A MackeyCentre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Australia.
Cathy WilliamsSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Seang-Mei SawSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Caroline C W KlaverDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jeremy A GuggenheimSchool of Optometry & Vision Sciences, Cardiff University, Cardiff, UK.
Joan E Bailey-WilsonComputational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD, USA.
CREAM Consortium
Erasmus MC · NLSingapore National Eye Center · SGKing's College London · GBCapital Medical University · CNCardiff University · GBJohannes Gutenberg University Mainz · DENational Institutes of Health · USSingapore Eye Research Institute · SGCentre for Eye Research Australia · AUDuke-NUS Medical School · SGGenome Institute of Singapore · SGHarvard University · USIRCCS Materno Infantile Burlo Garofolo · ITLions Eye Institute · AUMoorfields Eye Hospital NHS Foundation Trust · GBNational Research Council · ITNational University Hospital · SGNational University of Singapore · SGUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Bern · CH

Funding

Genetic Epidemiology of Complex TraitsZIAHG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$10.5M
Cancer Research UK C864/A14136Medical Research Council G1000143Medical Research Council G9815508Medical Research Council MR/K023721/1Wellcome TrustWellcome Trust 102215/2/13/2Wellcome Trust 508353/509506
6 · The paper itself

Abstract

Purpose: To identify genes and genetic markers associated with corneal astigmatism. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Cases were defined as having >0.75 diopters of corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts were performed using VEGAS2 and MAGMA software. Additionally, estimates of single nucleotide polymorphism (SNP)-based heritability for corneal and refractive astigmatism and the spherical equivalent were calculated for Europeans using LD score regression. Results: The meta-analysis of all cohorts identified a genome-wide significant locus near the platelet-derived growth factor receptor alpha ( Conclusions: In addition to replicating a previously identified genome-wide significant locus for corneal astigmatism near the

Indexed as

Acid PhosphataseAsian PeopleAstigmatismClaudinsCohort StudiesCorneaCorneal DiseasesGene ExpressionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracellular Signaling Peptides and ProteinsOdds RatioPolymorphism, Single NucleotideReceptor, Platelet-Derived Growth Factor alphaSoftwareAcid PhosphataseACP2 protein, humanClaudinsCLDN7 protein, humanIntracellular Signaling Peptides and ProteinsReceptor, Platelet-Derived Growth Factor alphaTNFAIP8L3 protein, human

Identifiers

PMID29422769
PMCPMC5800430
OpenAlexW2787388706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.