ArticleScientific reports2018
Clinical Translation of Tethered Confocal Microscopy Capsule for Unsedated Diagnosis of Eosinophilic Esophagitis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Endoluminal Procedures and Devices for Esophageal Tract Investigation: A Critical Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Label-free subcellular imaging with dynamic spectrally encoded confocal microscopy (D-SECM) with subpixel jitter correction.Biomedical optics express · 2026Article
- A review on computer-aided diagnostic system to classify the disorders of the gastrointestinal tract.European journal of medical research · 2025Review
- Low-cost, chromatic confocal endomicroscope for cellular imagingBiomedical optics express · 2021Article
- High-speed label-free confocal microscopy ofBiomedical optics express · 2021Article
- Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy.Clinical and translational gastroenterology · 2020Observational
- Artificial Intelligence Applied to Gastrointestinal Diagnostics: A Review.Journal of pediatric gastroenterology and nutrition · 2020Review
- Advancing patient care through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).The Journal of allergy and clinical immunology · 2020Review
- One-Hour Esophageal String Test: A Nonendoscopic Minimally Invasive Test That Accurately Detects Disease Activity in Eosinophilic Esophagitis.The American journal of gastroenterology · 2019Article
- Understanding optical reflectance contrast for real-time characterization of epithelial precursor lesions.Bioengineering & translational medicine · 2019Article
- Gastrointestinal diagnosis using non-white light imaging capsule endoscopy.Nature reviews. Gastroenterology & hepatology · 2019Review
- A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule.Lasers in surgery and medicine · 2019Article
- Ingestible Electronics for Diagnostics and Therapy.Nature reviews. Materials · 2019Article
- Microphotonic needle for minimally invasive endoscopic imaging with sub-cellular resolution.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Esophagogastroduodenoscopy (EGD) is a widely used procedure, posing significant financial burden on both healthcare systems and patients. Moreover, EGD is time consuming, sometimes difficult to tolerate, and suffers from an imperfect diagnostic yield as the limited number of collected biopsies does not represent the whole organ. In this paper, we report on technological and clinical feasibility of a swallowable tethered endomicroscopy capsule, which is administered without sedation, to image large regions of esophageal and gastric mucosa at the cellular level. To demonstrate imaging capabilities, we conducted a human pilot study (n = 17) on Eosinophilic Esophagitis (EoE) patients and healthy volunteers from which representative cases are presented and discussed. Results indicate that, compared to endoscopic biopsy, unsedated tethered capsule endomicroscopy obtains orders of magnitude more cellular information while successfully resolving characteristic tissue microscopic features such as stratified squamous epithelium, lamina propria papillae, intraepithelial eosinophils, and gastric cardia and body/fundic mucosa epithelia. Based on the major import of whole organ, cellular-level microscopy to obviate sampling error and the clear cost and convenience advantages of unsedated procedure, we believe that this tool has the potential to become a simpler and more effective device for diagnosing and monitoring the therapeutic response of EoE and other esophageal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.