ArticleScientific reports2018
Coordinated activation of a cluster of MMP genes in response to UVB radiation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 22 citations in OpenAlex.
- Protein Post-Translational Modifications in UV-Induced Skin Damage.Experimental dermatology · 2026Review
- WTAP stabilizes MMP12 expression to promote the malignant phenotypes of esophageal cancer cells.Regenerative therapy · 2026Article
- Oral Administration of Edible Snail Extract Powder Prevents UVB-Induced Skin Damage.Food science & nutrition · 2025Article
- Increased matrix metalloproteinase-1 expression by coexposure to UVA and cigarette sidestream smoke and contribution of histone acetylation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Article
- Review
- Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness.Biomedicines · 2024Review
- Identifying Suitable Reference Gene Candidates for Quantification of DNA Damage-Induced Cellular Responses in Human U2OS Cell Culture System.Biomolecules · 2023Article
- Super Enhancer-RegulatedCancers · 2022Article
- Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms.International journal of environmental research and public health · 2022Article
- In Vitro Anti-Photoaging and Skin Protective Effects ofPlants (Basel, Switzerland) · 2022Article
- UVB-mediated DNA damage induces matrix metalloproteinases to promote photoaging in an AhR- and SP1-dependent manner.JCI insight · 2022Article
- SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response.International journal of molecular sciences · 2021Article
- Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis.Redox biology · 2021Article
- Matrix metalloproteinases in keratinocyte carcinomas.Experimental dermatology · 2021Review
- The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis.Journal of lipid and atherosclerosis · 2020Review
- Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin.International journal of molecular sciences · 2019Article
- Propolis Extracts Inhibit UV-Induced Photodamage in Human Experimental In Vitro Skin Models.Antioxidants (Basel, Switzerland) · 2019Article
- UVB drives different stages of epigenome alterations during progression of skin cancer.Cancer letters · 2019Article
- Protective Effect of Baicalin Against TLR4-mediated UVA-induced Skin Inflammation.Photochemistry and photobiology · 2019Article
- SerpinB2 is involved in cellular response upon UV irradiation.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultraviolet (UV) B radiation is a dangerous environmental stressor, which can lead to photoaging, inflammation, immune suppression and tumour formation. A recent report has shown the transcriptional activation of several skin-specific genes including matrix metalloproteases (MMPs) in response to UV irradiation. Here, we use a novel human keratinocyte model, HKerE6SFM, to demonstrate that UVB activates the transcription of most members of the 11q22.3 MMP gene cluster including MMP13, MMP12, MMP3, MMP1 and MMP10. Curiously, the expression of the well-characterized UVB-inducible MMP9, which is located outside of the cluster, remains unchanged. In accordance with the increased expression of the MMP gene cluster upon UVB irradiation, RNA polymerase II showed increased occupancy at their promoters following UVB irradiation. The results also demonstrate increased acetylated histone H3K9 levels at the promoters of the MMP13, MMP12, MMP3, MMP1 and MMP10 genes. These findings suggest a coordinated transcriptional activation of genes in the MMP cluster at 11q22.3 and that acetylation of histone H3 at lysine 9 has an important role in the UVB-dependent enhancement of transcription of MMP genes in this region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.