Evidence map›Paper›PMID 29422606›Full record

ArticleScientific reports2018

Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function.

T L Leighton, M C Mok, M S Junop, P L Howell, L L Burrows

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Understanding phage Receptor-binding protein interaction with host surface receptor: the key for phage-Mediated detection and elimination of Pseudomonas aeruginosa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  3. Bacterial flagella hijack type IV pili proteins to control motility.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  4. Article
  5. Correlation ofEmerging microbes & infections · 2022
    Article
  6. Review
  7. Article
  8. Full Transcriptomic Response ofFrontiers in microbiology · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

T L LeightonDepartment of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.
M C MokDepartment of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada.
M S JunopDepartment of Biochemistry, Western University, London, ON, Canada.
P L HowellProgram in Molecular Structure & Function, The Hospital for Sick Children, Toronto, ON, Canada. howell@sickkids.ca.
L L BurrowsDepartment of Biochemistry and Biomedical Sciences and the Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON, Canada. burrowl@mcmaster.ca.ORCID 0000-0003-0838-5040

Funding

CIHR MOP-93585
6 · The paper itself

Abstract

Pseudomonas aeruginosa uses long, thin fibres called type IV pili (T4P) for adherence to surfaces, biofilm formation, and twitching motility. A conserved subcomplex of PilMNOP is required for extension and retraction of T4P. To better understand its function, we attempted to co-crystallize the soluble periplasmic portions of PilNOP, using reductive surface methylation to promote crystal formation. Only PilO

Indexed as

Amino Acid SequenceConserved SequenceBacterial ProteinsCrystallizationFimbriae, BacterialFimbriae ProteinsModels, MolecularMutagenesis, Site-DirectedProtein BindingProtein Structure, SecondaryPseudomonas aeruginosaBacterial ProteinsFimbriae Proteins

Identifiers

PMID29422606
PMCPMC5805733

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.